A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system. Approximately half of the patients with MS experience severe pain; However, currently available therapies provide only enough assistance. The mechanisms underlying the generation of neuropathic pain in patients with MS is not fully understood. More recently, we found that the neutrophil elastase of the accumulation of neutrophils in mechanical allodynia dorsal root ganglion (DRG) neurons and induces sensitive DRG in a mouse model of experimental autoimmune encephalomyelitis (EAE).

However, the underlying mechanisms of accumulation of neutrophils in DRG after myelin oligodendrocyte glycoprotein (MOG35-55, an immunogenic peptide) immunization is still unclear. Here, we found that the C-X-C motif ligand 1 (CXCL1) is regulated in DRG neurons after MOG35-55 immunization.

Increased CXCL1 protein expression was also observed in primary cultured DRG neurons treated with MOG35-55, mediated by toll like receptor 4 (TLR4). TLR4 gene silencing or CXCL1 in DRG neurons was significantly attenuated neutrophil accumulation in the DRG and mechanical allodynia during the preclinical phase of EAE (around day 5 after immunization). Our results thus demonstrate that TLR4 pathway-CXCL1 in DRG neurons in DRG triggers neutrophil recruitment and subsequent mechanical allodynia in response to MOG35-55.

DAPI

B1098-5 each
EUR 170.4

DAPI

abx082063-10mg 10 mg
EUR 276

DAPI

abx283157-100g 100 µg Ask for price

DAPI

abx283157-20g 20 µg
EUR 106.25

DAPI

abx283157-50g 50 µg
EUR 237.5

DAPI

abx082063-100l 100 µl
EUR 212.5

DAPI

abx082063-1ml 1 ml Ask for price

DAPI

abx082063-200l 200 µl Ask for price

DAPI

BMD0063-each each Ask for price

DAPI Dilactate

17509 25 mg
EUR 112
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI Dilactate

17509-25mg 25 mg
EUR 109
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI (hydrochloride)

C3362-10 10 mg
EUR 62
Description: A fluorescent probe, commonly used to stain DNA and chromosomes

DAPI (hydrochloride)

C3362-25 25 mg
EUR 130
Description: A fluorescent probe, commonly used to stain DNA and chromosomes

DAPI (hydrochloride)

C3362-5 5 mg
EUR 37
Description: A fluorescent probe, commonly used to stain DNA and chromosomes

DAPI Dihydrochloride

561706 5.0mg
EUR 190

DAPI Dihydrochloride

T19827-10mg 10mg Ask for price
Description: DAPI Dihydrochloride

DAPI Dihydrochloride

T19827-1g 1g Ask for price
Description: DAPI Dihydrochloride

DAPI Dihydrochloride

T19827-1mg 1mg Ask for price
Description: DAPI Dihydrochloride

DAPI Dihydrochloride

T19827-50mg 50mg Ask for price
Description: DAPI Dihydrochloride

DAPI Dihydrochloride

T19827-5mg 5mg Ask for price
Description: DAPI Dihydrochloride

DAPI (dihydrochloride)

HY-D0814 50mg
EUR 439.2

DAPI dihydrochloride

MB097-10MG 1 unit
EUR 41.98
Description: DAPI dihydrochloride

DAPI dihydrochloride

MB097-25MG 1 unit
EUR 83.31
Description: DAPI dihydrochloride

DAPI dihydrochloride

RM5773-25MG 1 unit
EUR 119.85
Description: DAPI dihydrochloride

DAPI Staining Kit

abx097206-1Kit 1 Kit
EUR 276

DAPI Staining Kit

abx097206-100l 100 µl
EUR 162.5

DAPI Staining Kit

abx097206-1ml 1 ml Ask for price

DAPI Staining Kit

abx097206-200l 200 µl Ask for price

FluorLast? with DAPI

1214-20 each
EUR 183.6

DAPI Reference Standard

BLI906A-1 1ml
EUR 265

DAPI Reference Standard

BLI906B-5 5ml
EUR 522

DAPI Reference Standard

BLI906C-14 2x7ml
EUR 1007

DAPI Reagent (25μg/mL)

E-CK-A163-100T 100T
EUR 15

DAPI Reagent (25μg/mL)

E-CK-A163-200T 200T
EUR 25

DAPI Reagent (25μg/mL)

E-CK-A163-500T 500T
EUR 55

DAPI Reagent (25μg/mL)

E-CK-A163-50T 50T
EUR 10

DAPI Solution(1mg/mL)

19178-91 1ML
EUR 38.5

DAPI Reagent (25ug/mL)

E-CK-A163-100Tests 100Tests
EUR 15

DAPI Reagent (25ug/mL)

E-CK-A163-200Tests 200Tests
EUR 25

DAPI Reagent (25ug/mL)

E-CK-A163-500Tests 500Tests
EUR 55

DAPI Reagent (25ug/mL)

E-CK-A163-50Tests 50Tests
EUR 10

DAPI-solution(1mg/ml)

E37F17510DZ 1-mL
EUR 60
Description: Cell-staining.-Nuclear-staining.

Fluoroshield™ with DAPI

AR-6501-01 20 ml
EUR 68.05

Fluoroshield™ with DAPI

AR-6501-02 100 ml
EUR 247.1

Fluoroshield with DAPI & PPD

AR-6513-01 20 ml
EUR 68.05

Fluoroshield with DAPI & PPD

AR-6513-02 100 ml
EUR 231

DAPI (Molecular Biology Grade)

CE117 5 mg
EUR 72

DAPI (Molecular Biology Grade)

CE118 25 mg
EUR 159.6

DAPI (Molecular Biology Grade)

CE119 100 mg
EUR 382.8

Fluoroshield with DAPI & DABCO

AR-6505-01 20 ml
EUR 68.05

Fluoroshield with DAPI & DABCO

AR-6505-02 100 ml
EUR 247.1

DAPI, 10mg/mL in H2O

40043-1 EA
EUR 103

DAPI Reagent (1 ug/mL)

E-IR-R103-10mL 10mL
EUR 35

DAPI Reagent (1 ug/mL)

E-IR-R103-50mL 50mL
EUR 105

DAPI Reagent (1 ug/mL)

E-IR-R103-5mL 5mL
EUR 20

DAPI Reagent (1 ug/mL)

E-IR-R103-each each Ask for price

Fluoroshield with DAPI & Propylgallate

AR-6506-01 20 ml
EUR 68.05

Fluoroshield with DAPI & Propylgallate

AR-6506-02 100 ml
EUR 247.1

FluorLast? with DAPI and DABCO

1218-20 each
EUR 183.6

Fluoromount Mounting Medium with DAPI

42734051-1 20 mL
EUR 76.14

FluoroQuestâ„¢ Mounting Medium with DAPI

20004 50 mL
EUR 112
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears.

FluoroQuestâ„¢ Mounting Medium with DAPI

20004-50mL 50 mL
EUR 109
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears.

OOSB00007-20ML - Dapi-Fluoromount-G

OOSB00007-20ML 20mL
EUR 79

DAPI staining kit (ready to use) 

EGY0621 10mL
EUR 85

DAPI staining kit (ready to use) 

EGY0622 50mL
EUR 185

Annexin V-PE/DAPI Apoptosis Kit

E-CK-A256-100Assays 100 Assays
EUR 260

Annexin V-PE/DAPI Apoptosis Kit

E-CK-A256-200Assays 200 Assays
EUR 398

Annexin V-PE/DAPI Apoptosis Kit

E-CK-A256-20Assays 20 Assays
EUR 75

Annexin V-PE/DAPI Apoptosis Kit

E-CK-A256-50Assays 50 Assays
EUR 150

Annexin V-APC/DAPI Apoptosis Kit

E-CK-A258-100Assays 100 Assays
EUR 260

Annexin V-APC/DAPI Apoptosis Kit

E-CK-A258-200Assays 200 Assays
EUR 398

Annexin V-APC/DAPI Apoptosis Kit

E-CK-A258-20Assays 20 Assays
EUR 75

Annexin V-APC/DAPI Apoptosis Kit

E-CK-A258-50Assays 50 Assays
EUR 150

Annexin V-FITC/DAPI Apoptosis Kit

E-CK-A252-100Assays 100 Assays
EUR 260

Annexin V-FITC/DAPI Apoptosis Kit

E-CK-A252-200Assays 200 Assays
EUR 398

Annexin V-FITC/DAPI Apoptosis Kit

E-CK-A252-20Assays 20 Assays
EUR 75

Annexin V-FITC/DAPI Apoptosis Kit

E-CK-A252-50Assays 50 Assays
EUR 150

Annexin V-EGFP/DAPI Apoptosis Kit

E-CK-A260-100Assays 100 Assays
EUR 260

Annexin V-EGFP/DAPI Apoptosis Kit

E-CK-A260-200Assays 200 Assays
EUR 398

Annexin V-EGFP/DAPI Apoptosis Kit

E-CK-A260-20Assays 20 Assays
EUR 75

Annexin V-EGFP/DAPI Apoptosis Kit

E-CK-A260-50Assays 50 Assays
EUR 150

Annexin V-AF647/DAPI Apoptosis Kit

E-CK-A254-100Assays 100 Assays
EUR 260

Annexin V-AF647/DAPI Apoptosis Kit

E-CK-A254-200Assays 200 Assays
EUR 398

Annexin V-AF647/DAPI Apoptosis Kit

E-CK-A254-20Assays 20 Assays
EUR 75

Annexin V-AF647/DAPI Apoptosis Kit

E-CK-A254-50Assays 50 Assays
EUR 150

Annexin V-AF488/DAPI Apoptosis Kit

E-CK-A278-100Assays 100 Assays
EUR 260

Annexin V-AF488/DAPI Apoptosis Kit

E-CK-A278-200Assays 200 Assays
EUR 398

Annexin V-AF488/DAPI Apoptosis Kit

E-CK-A278-20Assays 20 Assays
EUR 75

Annexin V-AF488/DAPI Apoptosis Kit

E-CK-A278-50Assays 50 Assays
EUR 150

Annexin V-ER780/DAPI Apoptosis Kit

E-CK-A280-100Assays 100 Assays
EUR 260

Annexin V-ER780/DAPI Apoptosis Kit

E-CK-A280-200Assays 200 Assays
EUR 398

Annexin V-ER780/DAPI Apoptosis Kit

E-CK-A280-20Assays 20 Assays
EUR 75

Annexin V-ER780/DAPI Apoptosis Kit

E-CK-A280-50Assays 50 Assays
EUR 150

DAPI blue fluorescent nuclear DNA dye

6244 10 mg
EUR 120.5

Anti-Fade Mounting Medium (With DAPI)

abx090690-10ml 10 ml
EUR 243.6

Anti-Fade Mounting Medium (With DAPI)

abx090690-100l 100 µl
EUR 137.5

Anti-Fade Mounting Medium (With DAPI)

abx090690-1ml 1 ml Ask for price

Anti-Fade Mounting Medium (With DAPI)

abx090690-200l 200 µl Ask for price

DAPI in Fluorguard™ (0.3 µg/ml)

F201 1 ml Ask for price

DAPI in Fluorguard™ (0.5 µg/ml)

F203 1 ml Ask for price

DAPI in Fluorguard™ (1 µg/ml)

F204 1 ml Ask for price

EverBrite™ Mounting Medium with DAPI

23002-1 EA
EUR 172

Annexin V-Cyanine5/DAPI Apoptosis Kit

E-CK-A262-100Assays 100 Assays
EUR 260

Annexin V-Cyanine5/DAPI Apoptosis Kit

E-CK-A262-200Assays 200 Assays
EUR 398

Annexin V-Cyanine5/DAPI Apoptosis Kit

E-CK-A262-20Assays 20 Assays
EUR 75

Annexin V-Cyanine5/DAPI Apoptosis Kit

E-CK-A262-50Assays 50 Assays
EUR 150

Annexin V-PE/TR/DAPI Apoptosis Kit

E-CK-A272-100Assays 100 Assays
EUR 260

Annexin V-PE/TR/DAPI Apoptosis Kit

E-CK-A272-200Assays 200 Assays
EUR 398

Annexin V-PE/TR/DAPI Apoptosis Kit

E-CK-A272-20Assays 20 Assays
EUR 75

Annexin V-PE/TR/DAPI Apoptosis Kit

E-CK-A272-50Assays 50 Assays
EUR 150

Immuno Fluoro Mount with DABCO and DAPI

AR-6519-01 20 ml
EUR 68.05

Immuno Fluoro Mount with DABCO and DAPI

AR-6519-02 100 ml
EUR 207.2

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit

E-CK-A264-100Assays 100 Assays
EUR 260

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit

E-CK-A264-200Assays 200 Assays
EUR 398

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit

E-CK-A264-20Assays 20 Assays
EUR 75

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit

E-CK-A264-50Assays 50 Assays
EUR 150

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit

E-CK-A266-100Assays 100 Assays
EUR 260

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit

E-CK-A266-200Assays 200 Assays
EUR 398

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit

E-CK-A266-20Assays 20 Assays
EUR 75

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit

E-CK-A266-50Assays 50 Assays
EUR 150

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit

E-CK-A268-100Assays 100 Assays
EUR 260

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit

E-CK-A268-200Assays 200 Assays
EUR 398

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit

E-CK-A268-20Assays 20 Assays
EUR 75

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit

E-CK-A268-50Assays 50 Assays
EUR 150

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit

E-CK-A270-100Assays 100 Assays
EUR 260

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit

E-CK-A270-200Assays 200 Assays
EUR 398

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit

E-CK-A270-20Assays 20 Assays
EUR 75

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit

E-CK-A270-50Assays 50 Assays
EUR 150

Fluorescent Mounting Medium with DAPI, 18 ml

E19-18 -
EUR 125

Glycerol mounting medium with DAPI and DABCO

AR-6510-01 20 ml
EUR 68.05

Glycerol mounting medium with DAPI and DABCO

AR-6510-02 100 ml
EUR 207.2

DAPI (4',6-Diamidino-2-phenylindole dihy

PCT1539-25MG 1 unit
EUR 77.94
Description: DAPI (4',6-Diamidino-2-phenylindole dihy

DAPI (4',6-Diamidino-2-phenylindole dihy

PCT1539-5MG 1 unit
EUR 18.69
Description: DAPI (4',6-Diamidino-2-phenylindole dihy

EverBrite™ Hardset Mounting Medium with DAPI

23004-1 EA
EUR 194

FluoroQuestâ„¢ Anti-fading Mounting Medium with DAPI

20005 20 mL
EUR 216
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears.

FluoroQuestâ„¢ Anti-fading Mounting Medium with DAPI

20005-20mL 20 mL
EUR 211
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears.

DAPI-[4',6-Diamidino-2-phenylindole,-dihydrochloride]

E37F17510 10-mg
EUR 260
Description: Cell-staining.-Nuclear-staining.

Anti-fluorescence quenching sealing Kit (including DAPI)

EGY073 100T
EUR 60

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride)

B551 0.2 ml
EUR 85

EverBrite TrueBlack® Hardset Mounting Medium with DAPI

23018-1 EA
EUR 327

EverBrite TrueBlack® Hardset Mounting Medium with DAPI

23018-T 1ML
EUR 88
Description: N/A

EverBrite TrueBlack® Hardset Mounting Medium with DAPI

23018-T-1 EA
EUR 88

SuperKine™ Enhanced Antifade Mounting Medium with DAPI

BMU107-EN-10mL 10 mL
EUR 39
Description: SuperKine™ Enhanced Antifade Mounting Medium with DAPI is compatible with a wide range of fluorescent dyes and protects the entire visible and infrared spectrum from fluorescence signal quenching.

SuperKine™ Enhanced Antifade Mounting Medium with DAPI

BMU107-EN-50mL 50 mL
EUR 69
Description: SuperKine™ Enhanced Antifade Mounting Medium with DAPI is compatible with a wide range of fluorescent dyes and protects the entire visible and infrared spectrum from fluorescence signal quenching.

SuperKine™ Enhanced Antifade Mounting Medium with DAPI

BMU107-EN-each each Ask for price

4’,6-Diamidino-2-phenylindole dihydrochloride (DAPI)

09224-10 10mg
EUR 129
Description: 28718-90-3

4’,6-Diamidino-2-phenylindole dihydrochloride (DAPI)

09224-50 50mg
EUR 494
Description: 28718-90-3

DAPI, dilactate (4’, 6-diamidino-2-phenylindole, dilactate)

40009-1 EA
EUR 123

Drop-n-Stain EverBrite™ Mounting Medium with DAPI

23009-1 EA
EUR 178

Drop-n-Stain EverBrite™ Mounting Medium with DAPI

23009-T 1ML
EUR 45
Description: N/A

Drop-n-Stain EverBrite™ Mounting Medium with DAPI

23009-T-1 EA
EUR 45

IHC-Tek DAPI Counterstain Solution, Ready To Use, 50 ml

IW-1404 -
EUR 65

Fluoro-KEEPER Antifade Reagent, Non-Hardening Type with DAPI

12745-74 2X5ML
EUR 133

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17510 10 mg
EUR 88
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17510-10mg 10 mg
EUR 86
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17511 100 mg
EUR 227
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17511-100mg 100 mg
EUR 222
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17513 25 mg
EUR 112
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17513-25mg 25 mg
EUR 109
Description: DAPI is a fluorescent stain that binds strongly to DNA.

Human 4’,6-Diamidino-2-phenylindole dihydrochloride(DAPI)ELISA kit

QY-E05538 96T
EUR 433.2

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *10 mM solution in water*

17507 2 mL
EUR 88
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *10 mM solution in water*

17507-2mL 2 mL
EUR 86
Description: DAPI is a fluorescent stain that binds strongly to DNA.

Anti-fluorescence quenching sealing agent (Ready to use,DABCO, including DAPI)

EGY078 100T
EUR 60

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining

AR1176 10mL(100 assys)
EUR 78

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining

AR1177 50mL(500 assys)
EUR 121.2

Br-DAPI

T39967-10mg 10mg Ask for price
Description: Br-DAPI

Br-DAPI

T39967-1g 1g Ask for price
Description: Br-DAPI

Br-DAPI

T39967-1mg 1mg Ask for price
Description: Br-DAPI

Br-DAPI

T39967-50mg 50mg Ask for price
Description: Br-DAPI