A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice.

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system. Approximately half of the patients with MS experience severe pain; However, currently available therapies provide only enough assistance. The mechanisms underlying the generation of neuropathic pain in patients with MS is not fully understood. More recently, we found that the neutrophil elastase of the accumulation of neutrophils in mechanical allodynia dorsal root ganglion (DRG) neurons and induces sensitive DRG in a mouse model of experimental autoimmune encephalomyelitis (EAE).

However, the underlying mechanisms of accumulation of neutrophils in DRG after myelin oligodendrocyte glycoprotein (MOG35-55, an immunogenic peptide) immunization is still unclear. Here, we found that the C-X-C motif ligand 1 (CXCL1) is regulated in DRG neurons after MOG35-55 immunization.

Increased CXCL1 protein expression was also observed in primary cultured DRG neurons treated with MOG35-55, mediated by toll like receptor 4 (TLR4). TLR4 gene silencing or CXCL1 in DRG neurons was significantly attenuated neutrophil accumulation in the DRG and mechanical allodynia during the preclinical phase of EAE (around day 5 after immunization). Our results thus demonstrate that TLR4 pathway-CXCL1 in DRG neurons in DRG triggers neutrophil recruitment and subsequent mechanical allodynia in response to MOG35-55.

DAPI

BMD0063-100mg 100 mg
EUR 849
Description: DAPI is a popular blue fluorescent DNA dye.

DAPI

BMD0063-10mg 10 mg
EUR 119
Description: DAPI is a popular blue fluorescent DNA dye.

DAPI Dilactate

17509 25 mg
EUR 109

DAPI Dilactate

17509-25mg 25 mg
EUR 109
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI (hydrochloride)

C3362-10 10 mg
EUR 146.4

DAPI (hydrochloride)

C3362-25 25 mg
EUR 240

DAPI (hydrochloride)

C3362-5 5 mg
EUR 111.6

DAPI (dihydrochloride)

HY-D0814 50mg
EUR 439.2

DAPI Dihydrochloride

561706 5.0mg
EUR 190

DAPI Dihydrochloride

T19827-10mg 10mg Ask for price
Description: DAPI Dihydrochloride

DAPI Dihydrochloride

T19827-1g 1g Ask for price
Description: DAPI Dihydrochloride

DAPI Dihydrochloride

T19827-1mg 1mg Ask for price
Description: DAPI Dihydrochloride

DAPI Dihydrochloride

T19827-50mg 50mg Ask for price
Description: DAPI Dihydrochloride

DAPI Dihydrochloride

T19827-5mg 5mg Ask for price
Description: DAPI Dihydrochloride

DAPI Staining Kit

abx097206-1Kit 1 Kit
EUR 276

FluorLast? with DAPI

1214-20 each
EUR 183.6

DAPI Reference Standard

BLI906A-1 1ml
EUR 265

DAPI Reference Standard

BLI906B-5 5ml
EUR 522

DAPI Reference Standard

BLI906C-14 2x7ml
EUR 1007

DAPI Reagent (25μg/mL)

E-CK-A163-100T 100T
EUR 15

DAPI Reagent (25μg/mL)

E-CK-A163-200T 200T
EUR 25

DAPI Reagent (25μg/mL)

E-CK-A163-500T 500T
EUR 55

DAPI Reagent (25μg/mL)

E-CK-A163-50T 50T
EUR 10

DAPI Solution(1mg/mL)

19178-91 1ML
EUR 38.5

DAPI-solution(1mg/ml)

E37F17510DZ 1-mL
EUR 60
Description: Cell-staining.-Nuclear-staining.

DAPI (Molecular Biology Grade)

CE117 5 mg
EUR 72

DAPI (Molecular Biology Grade)

CE118 25 mg
EUR 159.6

DAPI (Molecular Biology Grade)

CE119 100 mg
EUR 382.8

DAPI, 10mg/mL in H2O

40043-1 EA
EUR 103

FluorLast? with DAPI and DABCO

1218-20 each
EUR 183.6

Fluoromount Mounting Medium with DAPI

42734051-1 20 mL
EUR 76.14

FluoroQuestâ„¢ Mounting Medium with DAPI

20004-50mL 50 mL
EUR 109
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears.

OOSB00007-20ML - Dapi-Fluoromount-G

OOSB00007-20ML 20mL
EUR 79

DAPI staining kit (ready to use) 

EGY0621 10mL
EUR 85

DAPI staining kit (ready to use) 

EGY0622 50mL
EUR 185

Annexin V-PE/DAPI Apoptosis Kit

E-CK-A256-100Assays 100 Assays
EUR 260

Annexin V-PE/DAPI Apoptosis Kit

E-CK-A256-200Assays 200 Assays
EUR 398

Annexin V-PE/DAPI Apoptosis Kit

E-CK-A256-20Assays 20 Assays
EUR 75

Annexin V-PE/DAPI Apoptosis Kit

E-CK-A256-50Assays 50 Assays
EUR 150

Annexin V-APC/DAPI Apoptosis Kit

E-CK-A258-100Assays 100 Assays
EUR 260

Annexin V-APC/DAPI Apoptosis Kit

E-CK-A258-200Assays 200 Assays
EUR 398

Annexin V-APC/DAPI Apoptosis Kit

E-CK-A258-20Assays 20 Assays
EUR 75

Annexin V-APC/DAPI Apoptosis Kit

E-CK-A258-50Assays 50 Assays
EUR 150

Annexin V-FITC/DAPI Apoptosis Kit

E-CK-A252-100Assays 100 Assays
EUR 260

Annexin V-FITC/DAPI Apoptosis Kit

E-CK-A252-200Assays 200 Assays
EUR 398

Annexin V-FITC/DAPI Apoptosis Kit

E-CK-A252-20Assays 20 Assays
EUR 75

Annexin V-FITC/DAPI Apoptosis Kit

E-CK-A252-50Assays 50 Assays
EUR 150

Annexin V-EGFP/DAPI Apoptosis Kit

E-CK-A260-100Assays 100 Assays
EUR 260

Annexin V-EGFP/DAPI Apoptosis Kit

E-CK-A260-200Assays 200 Assays
EUR 398

Annexin V-EGFP/DAPI Apoptosis Kit

E-CK-A260-20Assays 20 Assays
EUR 75

Annexin V-EGFP/DAPI Apoptosis Kit

E-CK-A260-50Assays 50 Assays
EUR 150

Annexin V-AF647/DAPI Apoptosis Kit

E-CK-A254-100Assays 100 Assays
EUR 260

Annexin V-AF647/DAPI Apoptosis Kit

E-CK-A254-200Assays 200 Assays
EUR 398

Annexin V-AF647/DAPI Apoptosis Kit

E-CK-A254-20Assays 20 Assays
EUR 75

Annexin V-AF647/DAPI Apoptosis Kit

E-CK-A254-50Assays 50 Assays
EUR 150

Annexin V-AF488/DAPI Apoptosis Kit

E-CK-A278-100Assays 100 Assays
EUR 260

Annexin V-AF488/DAPI Apoptosis Kit

E-CK-A278-200Assays 200 Assays
EUR 398

Annexin V-AF488/DAPI Apoptosis Kit

E-CK-A278-20Assays 20 Assays
EUR 75

Annexin V-AF488/DAPI Apoptosis Kit

E-CK-A278-50Assays 50 Assays
EUR 150

Annexin V-ER780/DAPI Apoptosis Kit

E-CK-A280-100Assays 100 Assays
EUR 260

Annexin V-ER780/DAPI Apoptosis Kit

E-CK-A280-200Assays 200 Assays
EUR 398

Annexin V-ER780/DAPI Apoptosis Kit

E-CK-A280-20Assays 20 Assays
EUR 75

Annexin V-ER780/DAPI Apoptosis Kit

E-CK-A280-50Assays 50 Assays
EUR 150

Anti-Fade Mounting Medium (With DAPI)

abx090690-10ml 10 ml
EUR 243.6

DAPI blue fluorescent nuclear DNA dye

6244 10 mg
EUR 120.5

DAPI in Fluorguard™ (0.3 µg/ml)

F201 1 ml Ask for price

DAPI in Fluorguard™ (0.5 µg/ml)

F203 1 ml Ask for price

DAPI in Fluorguard™ (1 µg/ml)

F204 1 ml Ask for price

EverBrite™ Mounting Medium with DAPI

23002-1 EA
EUR 172

Annexin V-Cyanine5/DAPI Apoptosis Kit

E-CK-A262-100Assays 100 Assays
EUR 260

Annexin V-Cyanine5/DAPI Apoptosis Kit

E-CK-A262-200Assays 200 Assays
EUR 398

Annexin V-Cyanine5/DAPI Apoptosis Kit

E-CK-A262-20Assays 20 Assays
EUR 75

Annexin V-Cyanine5/DAPI Apoptosis Kit

E-CK-A262-50Assays 50 Assays
EUR 150

FluoroQuest™ Mounting Medium with DAPI

20004 50 mL
EUR 109

EverBrite Hardset Mounting Medium with DAPI

23004 10mL
EUR 255.6
Description: Minimum order quantity: 1 unit of 10mL

Annexin V-PE/TR/DAPI Apoptosis Kit

E-CK-A272-100Assays 100 Assays
EUR 260

Annexin V-PE/TR/DAPI Apoptosis Kit

E-CK-A272-200Assays 200 Assays
EUR 398

Annexin V-PE/TR/DAPI Apoptosis Kit

E-CK-A272-20Assays 20 Assays
EUR 75

Annexin V-PE/TR/DAPI Apoptosis Kit

E-CK-A272-50Assays 50 Assays
EUR 150

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit

E-CK-A264-100Assays 100 Assays
EUR 260

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit

E-CK-A264-200Assays 200 Assays
EUR 398

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit

E-CK-A264-20Assays 20 Assays
EUR 75

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit

E-CK-A264-50Assays 50 Assays
EUR 150

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit

E-CK-A266-100Assays 100 Assays
EUR 260

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit

E-CK-A266-200Assays 200 Assays
EUR 398

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit

E-CK-A266-20Assays 20 Assays
EUR 75

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit

E-CK-A266-50Assays 50 Assays
EUR 150

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit

E-CK-A268-100Assays 100 Assays
EUR 260

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit

E-CK-A268-200Assays 200 Assays
EUR 398

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit

E-CK-A268-20Assays 20 Assays
EUR 75

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit

E-CK-A268-50Assays 50 Assays
EUR 150

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit

E-CK-A270-100Assays 100 Assays
EUR 260

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit

E-CK-A270-200Assays 200 Assays
EUR 398

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit

E-CK-A270-20Assays 20 Assays
EUR 75

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit

E-CK-A270-50Assays 50 Assays
EUR 150

Fluorescent Mounting Medium with DAPI, 18 ml

E19-18 -
EUR 125

EverBrite™ Hardset Mounting Medium with DAPI

23004-1 EA
EUR 194

FluoroQuestâ„¢ Anti-fading Mounting Medium with DAPI

20005-20mL 20 mL
EUR 211
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears.

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride)

B551 0.2 ml
EUR 129.6

DAPI-[4',6-Diamidino-2-phenylindole,-dihydrochloride]

E37F17510 10-mg
EUR 260
Description: Cell-staining.-Nuclear-staining.

Anti-fluorescence quenching sealing Kit (including DAPI)

EGY073 100T
EUR 60

FluoroQuest™ Anti-fading Mounting Medium with DAPI

20005 20 mL
EUR 211

EverBrite TrueBlack® Hardset Mounting Medium with DAPI

23018-1 EA
EUR 327

EverBrite TrueBlack® Hardset Mounting Medium with DAPI

23018-T-1 EA
EUR 88

EverBrite TrueBlack® Hardset Mounting Medium with DAPI

23018 1ML
EUR 327
Description: N/A

EverBrite TrueBlack® Hardset Mounting Medium with DAPI

23018-T 1ML
EUR 88
Description: N/A

SuperKine™ Enhanced Antifade Mounting Medium with DAPI

BMU107-EN-10mL 10 mL
EUR 39
Description: SuperKine™ Enhanced Antifade Mounting Medium with DAPI is compatible with a wide range of fluorescent dyes and protects the entire visible and infrared spectrum from fluorescence signal quenching.

SuperKine™ Enhanced Antifade Mounting Medium with DAPI

BMU107-EN-50mL 50 mL
EUR 69
Description: SuperKine™ Enhanced Antifade Mounting Medium with DAPI is compatible with a wide range of fluorescent dyes and protects the entire visible and infrared spectrum from fluorescence signal quenching.

DAPI, dilactate (4’, 6-diamidino-2-phenylindole, dilactate)

40009-1 EA
EUR 123

4’,6-Diamidino-2-phenylindole dihydrochloride (DAPI)

09224-10 10mg
EUR 129
Description: 28718-90-3

4’,6-Diamidino-2-phenylindole dihydrochloride (DAPI)

09224-50 50mg
EUR 494
Description: 28718-90-3

Drop-n-Stain EverBrite™ Mounting Medium with DAPI

23009-1 EA
EUR 178

Drop-n-Stain EverBrite™ Mounting Medium with DAPI

23009-T-1 EA
EUR 45

Drop-n-Stain EverBrite™ Mounting Medium with DAPI

23009 1ML
EUR 178
Description: N/A

Drop-n-Stain EverBrite™ Mounting Medium with DAPI

23009-T 1ML
EUR 45
Description: N/A

IHC-Tek DAPI Counterstain Solution, Ready To Use, 50 ml

IW-1404 -
EUR 65

Fluoro-KEEPER Antifade Reagent, Non-Hardening Type with DAPI

12745-74 2X5ML
EUR 133

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17510 10 mg
EUR 86

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17511 100 mg
EUR 222

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17513 25 mg
EUR 109

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17510-10mg 10 mg
EUR 86
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17511-100mg 100 mg
EUR 222
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17513-25mg 25 mg
EUR 109
Description: DAPI is a fluorescent stain that binds strongly to DNA.

Human 4’,6-Diamidino-2-phenylindole dihydrochloride(DAPI)ELISA kit

QY-E05538 96T
EUR 433.2

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *10 mM solution in water*

17507 2 mL
EUR 86

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *10 mM solution in water*

17507-2mL 2 mL
EUR 86
Description: DAPI is a fluorescent stain that binds strongly to DNA.

Anti-fluorescence quenching sealing agent (Ready to use,DABCO, including DAPI)

EGY078 100T
EUR 60

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining

AR1176 10mL(100 assys)
EUR 78

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining

AR1177 50mL(500 assys)
EUR 121.2

Br-DAPI

T39967-10mg 10mg Ask for price
Description: Br-DAPI

Br-DAPI

T39967-1g 1g Ask for price
Description: Br-DAPI

Br-DAPI

T39967-1mg 1mg Ask for price
Description: Br-DAPI

Br-DAPI

T39967-50mg 50mg Ask for price
Description: Br-DAPI

Br-DAPI

T39967-5mg 5mg Ask for price
Description: Br-DAPI

Dapivirine

HY-14266 5mg
EUR 183.6

Dapivirine

317132 10.0mg
EUR 90

Dapivirine

T1815-10mg 10mg Ask for price
Description: Dapivirine

Dapivirine

T1815-1g 1g Ask for price
Description: Dapivirine

Dapivirine

T1815-1mg 1mg Ask for price
Description: Dapivirine

Dapivirine

T1815-50mg 50mg Ask for price
Description: Dapivirine

Dapivirine

T1815-5mg 5mg Ask for price
Description: Dapivirine

Dapiglutide

T39820-10mg 10mg Ask for price
Description: Dapiglutide

Dapiglutide

T39820-1g 1g Ask for price
Description: Dapiglutide

Dapiglutide

T39820-1mg 1mg Ask for price
Description: Dapiglutide

Dapiglutide

T39820-50mg 50mg Ask for price
Description: Dapiglutide

Dapiglutide

T39820-5mg 5mg Ask for price
Description: Dapiglutide

Dapiprazole

T21381-10mg 10mg Ask for price
Description: Dapiprazole

Dapiprazole

T21381-1g 1g Ask for price
Description: Dapiprazole

Dapiprazole

T21381-1mg 1mg Ask for price
Description: Dapiprazole

Dapiprazole

T21381-50mg 50mg Ask for price
Description: Dapiprazole

Dapiprazole

T21381-5mg 5mg Ask for price
Description: Dapiprazole

Dapiprazole HCl

540098 10.0mg
EUR 210

Dapirolizumab

E40YR1323 1 mg
EUR 2960
Description: Available in various conjugation types.

D-Apiose dericate

T60049-10mg 10mg Ask for price
Description: D-Apiose dericate

D-Apiose dericate

T60049-1g 1g Ask for price
Description: D-Apiose dericate

D-Apiose dericate

T60049-1mg 1mg Ask for price
Description: D-Apiose dericate

D-Apiose dericate

T60049-50mg 50mg Ask for price
Description: D-Apiose dericate

D-Apiose dericate

T60049-5mg 5mg Ask for price
Description: D-Apiose dericate

Dapivirine (TMC120)

A8554-25 25 mg
EUR 517.2
Description: Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor with a favorable safety profile following vaginal application.

Dapivirine (TMC120)

A8554-5 5 mg
EUR 201.6
Description: Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor with a favorable safety profile following vaginal application.

Dapivirine (TMC120)

A8554-5.1 10 mM (in 1mL DMSO)
EUR 212.4
Description: Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor with a favorable safety profile following vaginal application.

Ethyl β-D-apiofuranoside

TN5806-10mg 10mg Ask for price
Description: Ethyl β-D-apiofuranoside

Ethyl β-D-apiofuranoside

TN5806-1g 1g Ask for price
Description: Ethyl β-D-apiofuranoside

Ethyl β-D-apiofuranoside

TN5806-1mg 1mg Ask for price
Description: Ethyl β-D-apiofuranoside

Ethyl β-D-apiofuranoside

TN5806-50mg 50mg Ask for price
Description: Ethyl β-D-apiofuranoside

Ethyl β-D-apiofuranoside

TN5806-5mg 5mg Ask for price
Description: Ethyl β-D-apiofuranoside

Dapiprazole (hydrochloride)

HY-A0142A 25mg
EUR 241.2

Dapiprazole Hydrochloride

T3996-10mg 10mg Ask for price
Description: Dapiprazole Hydrochloride

Dapiprazole Hydrochloride

T3996-1g 1g Ask for price
Description: Dapiprazole Hydrochloride