Restoration of neuronal connectivity after a lesion of the central nervous system, such as spinal cord injury, is one of the greatest challenges in modern medicine. In particular, the accumulation of factors inhibiting the growth of axons at the site of injury is a major obstacle to the improvement of structural and thus functional.
We previously investigated prenylflavonoids group derived from hops to their capacity to promote neuroregeneration. We identified a molecule called ENDF1 a very powerful tool to increase the re-growth and branching of neurites of dorsal root ganglion neurons in culture in promoting the growth substrate.
In this study, we investigated the capacity ENDF1 to promote regeneration of rat dorsal root ganglion neurons in vitro in the presence of the three main components of the extracellular matrix that acts as an inhibitor of axon growth: semaphorin 3A, Ephrin A4 and mixed with chondroitin sulfate proteoglycans. We reported that ENDF1 application significantly promoted the percentage of sensory neurons were able to regrow their neurites irrespective of their presence inhibitor, and this to an extent similar to that obtained after NGF treatment. In addition, the greatly enhanced ENDF1 total neurite length and complexity of neurites extending from neurons challenged with axon growth inhibitors.
Although the effects of NGF and ENDF1 on regeneration of neurons was similar, ENDF1 activity is not mediated by signaling through TrkA receptor, suggesting that each molecule acts via different signaling pathways. Additionally, ENDF1 not degrade cofilin phosphorylation, downstream effectors associated regeneration of RhoA / ROCK signaling pathway. Therefore, ENDF1 is pro-neuroregenerative potent factor that may help in identifying new efficient targets for regenerative therapies of the nervous system.
DAB Buffer, 10X For use with DAB Staining System for HRPO |
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MBS639268-50mL | MyBiosource | 50mL | EUR 280 |
DAB Buffer, 10X For use with DAB Staining System for HRPO |
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MBS639268-5x500mL | MyBiosource | 5x500mL | EUR 2090 |
SensiTek HRP Anti-Mouse (DAB) Staining System |
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AEA080 | ScyTek Laboratories | 70 Slides | EUR 55.28 |
UltraTek HRP Anti-Mouse (DAB) Staining System |
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AKA080 | ScyTek Laboratories | 70 Slides | EUR 61.72 |
SensiTek HRP Anti-Rabbit (DAB) Staining System |
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AEI080 | ScyTek Laboratories | 70 Slides | EUR 55.28 |
UltraTek HRP Anti-Rabbit (DAB) Staining System |
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AKC080 | ScyTek Laboratories | 70 Slides | EUR 61.72 |
UltraTek HRP Anti-Polyvalent (DAB) Staining System |
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AMF080 | ScyTek Laboratories | 70 Slides | EUR 70.71 |
SensiTek HRP Anti-Polyvalent (DAB) Staining System |
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AEM080 | ScyTek Laboratories | 70 Slides | EUR 61.72 |
STAT-Q Multivalent DAB KIT for staining Mouse, Rat |
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NB314KLD | Innovex | 1000 slides | EUR 895 |
Description: STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 1000 plus slides (Large size kit) |
STAT-Q Multivalent DAB KIT for staining Mouse, Rat |
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NB314KLD-20 | Innovex | 300 slide kit | EUR 595 |
Description: STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 350 slides kit (Small size Kit) |
STAT-Q Goat DAB KIT for staining all Goat primary |
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NB314KLGD-20 | Innovex | 20 ml kit | EUR 589 |
Description: STAT-Q Goat DAB KIT for staining all Goat primary antibodies, 350 plus slides |
STAT-Q Rabbit DAB KIT for staining all Rabbit anti |
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NB314KLRD-20 | Innovex | 20 ml kit | EUR 585 |
Description: STAT-Q Rabbit DAB KIT for staining all Rabbit antibodies, 350 plus slides |
STAT-Q Mouse Adsorbed DAB KIT for staining Rat ant |
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NB314MAK-DAB | Innovex | 200-250 slides | EUR 695 |
Description: STAT-Q Mouse Adsorbed DAB KIT for staining Rat antibodies-on-Mouse tissues 250 plus slide kit |
STAT-Q Rat Adsorbed DAB KIT for staining Mouse ant |
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NB314RAK-DAB | Innovex | 200-250 slides | EUR 695 |
Description: STAT-Q Rat Adsorbed DAB KIT for staining Mouse antibodies-on-Rat tissues 250 plus slides kit |
DAB Stable Liquid Substrate 50X Concentrate, 0.0694mM Staining System for HRPO |
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MBS639197-100mL | MyBiosource | 100mL | EUR 715 |
DAB Stable Liquid Substrate 50X Concentrate, 0.0694mM Staining System for HRPO |
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MBS639197-10mL | MyBiosource | 10mL | EUR 300 |
DAB Stable Liquid Substrate 50X Concentrate, 0.0694mM Staining System for HRPO |
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MBS639197-25mL | MyBiosource | 25mL | EUR 380 |
DAB Stable Liquid Substrate 50X Concentrate, 0.0694mM Staining System for HRPO |
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MBS639197-5x100mL | MyBiosource | 5x100mL | EUR 3075 |
STAT Double Staining ragent for Double staining Mo |
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NB330DB | Innovex | 25 ml | EUR 595 |
Description: STAT Double Staining ragent for Double staining Mouse and Sheep antibodies, 450 Plus slides |
STAT Double Staining reagent for Double staining o |
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NB326DB | Innovex | 25 ml | EUR 595 |
Description: STAT Double Staining reagent for Double staining of Mouse and Rabbit antibodies, 450 plus slides |
STAT Double Staining Reagent for Double staining o |
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NB327DB | Innovex | 25 ml | EUR 595 |
Description: STAT Double Staining Reagent for Double staining of Mouse and Goat antibodies, 450 plus slides |
PI Staining Kit |
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abx097208-1Kit | Abbexa | 1 Kit | EUR 276 |
HE Staining Kit |
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E-IR-R117-100mL | Elabscience Biotech | 100mL | EUR 240 |
HE Staining Kit |
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E-IR-R117-10mL | Elabscience Biotech | 10mL | EUR 35 |
HE Staining Kit |
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E-IR-R117-50mL | Elabscience Biotech | 50mL | EUR 150 |
HE Staining Kit |
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E-IR-R117-each | Elabscience Biotech | each | Ask for price |
PI Staining Kit |
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MBS826722-01mL | MyBiosource | 0.1mL | EUR 140 |
PI Staining Kit |
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MBS826722-5x01mL | MyBiosource | 5x0.1mL | EUR 550 |
HE staining Kit |
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MBS2567140-100mL | MyBiosource | 100mL | EUR 255 |
HE staining Kit |
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MBS2567140-10mL | MyBiosource | 10mL | EUR 120 |
HE staining Kit |
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MBS2567140-50mL | MyBiosource | 50mL | EUR 195 |
HE staining Kit |
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MBS2567140-5x100mL | MyBiosource | 5x100mL | EUR 1120 |
DAPI Staining Kit |
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abx097206-1Kit | Abbexa | 1 Kit | EUR 276 |
TRAP Staining Kit |
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KT-008 | Kamiya Biomedical Company | 1 kit | EUR 747 |
DAPI Staining Kit |
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abx097206-100l | Abbexa | 100 µl | EUR 162.5 |
DAPI Staining Kit |
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abx097206-1ml | Abbexa | 1 ml | Ask for price |
DAPI Staining Kit |
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abx097206-200l | Abbexa | 200 µl | Ask for price |
DAPI Staining Kit |
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MBS826728-01mL | MyBiosource | 0.1mL | EUR 140 |
DAPI Staining Kit |
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MBS826728-5x01mL | MyBiosource | 5x0.1mL | EUR 550 |
Coplin Staining Jar |
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08415-3 | Polysciences Europe GmbH | 3sets | EUR 84 |
Silver Staining Kit |
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ML123-1KT | EWC Diagnostics | 1 unit | EUR 201.16 |
Description: Silver Staining Kit |
Cell Staining Buffer |
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E-CK-A107-100mL | Elabscience Biotech | 100 mL | EUR 20 |
Cell Staining Buffer |
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E-CK-A107-200mL | Elabscience Biotech | 200 mL | EUR 35 |
Cell Staining Buffer |
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E-CK-A107-500mL | Elabscience Biotech | 500 mL | EUR 60 |
Cell Staining Buffer |
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E16FXP005 | EnoGene | 500 ml | EUR 40 |
Description: Available in various conjugation types. |
DNA Staining Reagent |
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abx299713-100g | Abbexa | 100 µg | Ask for price |
DNA Staining Reagent |
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abx299713-20g | Abbexa | 20 µg | EUR 300 |
DNA Staining Reagent |
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abx299713-50g | Abbexa | 50 µg | Ask for price |
Cell Staining Buffer |
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E-CK-A107-each | Elabscience Biotech | each | Ask for price |
Cell Staining Buffer |
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MBS679239-500mL | MyBiosource | 500mL | EUR 185 |
Cell Staining Buffer |
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MBS679239-5x500mL | MyBiosource | 5x500mL | EUR 675 |
Cell Staining Buffer |
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MBS679240-100mL | MyBiosource | 100mL | EUR 130 |
Cell Staining Buffer |
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MBS679240-5x100mL | MyBiosource | 5x100mL | EUR 435 |
Cell Staining Buffer |
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MBS679241-250mL | MyBiosource | 250mL | EUR 145 |
Cell Staining Buffer |
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MBS679241-5x250mL | MyBiosource | 5x250mL | EUR 515 |
Cell Staining Buffer |
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MBS2567126-100mL | MyBiosource | 100mL | EUR 90 |
Cell Staining Buffer |
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MBS2567126-200mL | MyBiosource | 200mL | EUR 100 |
Cell Staining Buffer |
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MBS2567126-500mL | MyBiosource | 500mL | EUR 125 |
Cell Staining Buffer |
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MBS2567126-5x500mL | MyBiosource | 5x500mL | EUR 545 |
DAPI Staining Solution |
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MBS176580-10mL | MyBiosource | 10mL | EUR 115 |
DAPI Staining Solution |
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MBS176580-50mL | MyBiosource | 50mL | EUR 135 |
DAPI Staining Solution |
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MBS176580-5x50mL | MyBiosource | 5x50mL | EUR 450 |
jetBlue Protein Staining Solution |
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MBS402061-20mL | MyBiosource | 20mL | EUR 165 |
jetBlue Protein Staining Solution |
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MBS402061-500mL | MyBiosource | 500mL | EUR 210 |
Wright Staining Solution |
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K1182-100 | ApexBio | 100ml | EUR 40 |
Description: Cell Biology|Staining Solution |
Wright Staining Solution |
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K1182-500 | ApexBio | 500ml | EUR 64 |
Description: Cell Biology|Staining Solution |
ELVIS ID Staining Kit |
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SK-ELVIS-100 | Quidel | 100 Tests | Ask for price |
ELVIS ID Staining Kit |
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SK-ELVIS-1000 | Quidel | 1000 Tests | Ask for price |
ELVIS ID Staining Kit |
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SK-ELVIS-200 | Quidel | 200 Tests | Ask for price |
ELVIS ID Staining Kit |
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SK-ELVIS-500 | Quidel | 500 Tests | Ask for price |
Colloidal Protein Staining Solution |
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51581 | Sisco Laboratories | 100 ml | EUR 25.5 |
Description: Part B |
Hoechst 33342 Staining Kit |
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abx097207-1Kit | Abbexa | 1 Kit | EUR 276 |
Hoechst 33342 Staining Kit |
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abx097207-100l | Abbexa | 100 µl | EUR 162.5 |
Hoechst 33342 Staining Kit |
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abx097207-1ml | Abbexa | 1 ml | Ask for price |
Hoechst 33342 Staining Kit |
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abx097207-200l | Abbexa | 200 µl | Ask for price |
Hoechst 33342 Staining Kit |
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MBS826727-01mL | MyBiosource | 0.1mL | EUR 140 |
Hoechst 33342 Staining Kit |
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MBS826727-5x01mL | MyBiosource | 5x0.1mL | EUR 550 |
Leishman Staining Solution |
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68015 | Sisco Laboratories | 250 ml | EUR 2.05 |
Description: Part A |
DNA STAINING AGENT (1ML) |
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NOVELJUICE | Consort | each | EUR 80 |
Hematoxylin Staining Buffer |
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E-IR-R120-15mL | Elabscience Biotech | 15mL | EUR 60 |
Hematoxylin Staining Buffer |
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E-IR-R120-50mL | Elabscience Biotech | 50mL | EUR 170 |
Hematoxylin Staining Buffer |
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E-IR-R120-5mL | Elabscience Biotech | 5mL | EUR 25 |
Hematoxylin Staining Buffer |
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E-IR-R120-each | Elabscience Biotech | each | Ask for price |
Hematoxylin staining Buffer |
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MBS2567138-15mL | MyBiosource | 15mL | EUR 125 |
Hematoxylin staining Buffer |
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MBS2567138-50mL | MyBiosource | 50mL | EUR 190 |
Hematoxylin staining Buffer |
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MBS2567138-5mL | MyBiosource | 5mL | EUR 95 |
Hematoxylin staining Buffer |
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MBS2567138-5x50mL | MyBiosource | 5x50mL | EUR 815 |
Cartilage Staining Solution |
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MBS355813-100mL | MyBiosource | 100mL | EUR 185 |
Cartilage Staining Solution |
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MBS355813-5x100mL | MyBiosource | 5x100mL | EUR 530 |
Cell Cycle Staining Kit |
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KTA2020-each | Abbkine | each | Ask for price |
Cell Cycle Staining Kit |
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KTA2020-100T | Abbkine | 100 T | EUR 119 |
Description: Abbkine Cell Cycle Staining Kit provides a convenient and accurate determination of the percentage of cells in each phase of the cell cycle. |
Cell Cycle Staining Kit |
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KTA2020-50T | Abbkine | 50 T | EUR 69 |
Description: Abbkine Cell Cycle Staining Kit provides a convenient and accurate determination of the percentage of cells in each phase of the cell cycle. |
Cell Cycle Staining Kit |
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MBS9718793-100Tests | MyBiosource | 100Tests | EUR 225 |
Cell Cycle Staining Kit |
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MBS9718793-500Tests | MyBiosource | 500Tests | EUR 355 |
Cell Cycle Staining Kit |
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MBS9718793-50Tests | MyBiosource | 50Tests | EUR 195 |
Cell Cycle Staining Kit |
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MBS9718793-5x500Tests | MyBiosource | 5x500Tests | EUR 1580 |
HISTOCHEMISTRY STAINING TRAY |
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ATC-12 | IBI Scientific | 12 PLACE - CLEAR LID | EUR 226.1 |
HISTOCHEMISTRY STAINING TRAY |
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ATC-24 | IBI Scientific | 24 PLACE - CLEAR LID | EUR 342.21 |
HISTOCHEMISTRY STAINING TRAY |
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AT-12 | IBI Scientific | 12 PLACE - BLACK LID | EUR 226.1 |
HISTOCHEMISTRY STAINING TRAY |
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AT-24 | IBI Scientific | 24 PLACE - BLACK LID | EUR 342.21 |
Exosome fluorescent staining |
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S104 | 101Bio | - | EUR 800 |
PI / RNase Staining Buffer |
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20-abx090619 | Abbexa |
|
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Live NucRed staining kit |
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EGY069 | EnoGene | >100T | EUR 210 |
PI / RNase Staining Buffer |
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abx090619-100l | Abbexa | 100 µl | EUR 162.5 |
PI / RNase Staining Buffer |
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abx090619-1ml | Abbexa | 1 ml | Ask for price |
PI / RNase Staining Buffer |
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abx090619-200l | Abbexa | 200 µl | EUR 200 |
Live NucRed staining kit |
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MBS8584964-100Tests | MyBiosource | 100Tests | EUR 310 |
Live NucRed staining kit |
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MBS8584964-5x100Tests | MyBiosource | 5x100Tests | EUR 1405 |
PI / RNase Staining Buffer |
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MBS355225-100Tests | MyBiosource | 100Tests | EUR 255 |
PI / RNase Staining Buffer |
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MBS355225-50Tests | MyBiosource | 50Tests | EUR 215 |
PI / RNase Staining Buffer |
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MBS355225-5x100Tests | MyBiosource | 5x100Tests | EUR 845 |
ProsiBlue Gel Staining Solution |
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P7300-050 | GenDepot | 500ml | EUR 208.8 |
Stains All Gel Staining Kit |
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KT-792 | Kamiya Biomedical Company | 20 tests | EUR 737 |
7-AAD Staining Solution |
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MBS669126-200Tests | MyBiosource | 200Tests | EUR 145 |
7-AAD Staining Solution |
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MBS669126-5x200Tests | MyBiosource | 5x200Tests | EUR 655 |
Ponceau S Protein Staining Solution |
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PS003-B500ML | Bio-Helix | 500 ml | EUR 25 |
Live NucGreen staining kit |
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EGY068 | EnoGene | >100T | EUR 210 |
Dead NucGreen staining kit |
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EGY070 | EnoGene | >100T | EUR 210 |
Live NucGreen staining kit |
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MBS8584963-100Tests | MyBiosource | 100Tests | EUR 310 |
Live NucGreen staining kit |
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MBS8584963-5x100Tests | MyBiosource | 5x100Tests | EUR 1405 |
Dead NucGreen staining kit |
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MBS8584965-100Tests | MyBiosource | 100Tests | EUR 310 |
Dead NucGreen staining kit |
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MBS8584965-5x100Tests | MyBiosource | 5x100Tests | EUR 1405 |
GEL STAINING/INCUBATION BOX |
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SB-10 | IBI Scientific | LIGHT SHIELDING | EUR 94.44 |
QUANTOMTx IQ/OQ Protocol |
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LBQ14001 | Westburg | each | EUR 991.9 |
Ponceau S Staining Solution |
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41640009-1 | Glycomatrix | 500 mL | EUR 40.13 |
Ponceau S Staining Solution |
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41640009-2 | Glycomatrix | 1 L | EUR 58.16 |
Ponceau S Staining Solution |
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B7778-100000 | ApexBio | 100 g | EUR 78 |
Description: Rapid (5 min) staining of protein bands on nitrocellulose or PVDF membranes |
Ponceau S Staining Solution |
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B7778-50000 | ApexBio | 50 g | EUR 53 |
Description: Rapid (5 min) staining of protein bands on nitrocellulose or PVDF membranes |
Ponceau S Staining Solution |
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14092 | Sisco Laboratories | 100 ml | EUR 13.13 |
Description: Part B |
Ponceau S Staining Solution |
|||
EZWB08-1x-100mL | Shanghai WSHT Biotechnology | 100mL | EUR 9.6 |
Ponceau S Staining Solution |
|||
EZWB08-1x-500mL | Shanghai WSHT Biotechnology | 500mL | EUR 32.4 |
Giemsa Staining Solution (10X) |
|||
K1181-100 | ApexBio | 100ml | EUR 40 |
Description: Cell Biology|Staining Solution |
Giemsa Staining Solution (10X) |
|||
K1181-500 | ApexBio | 500ml | EUR 64 |
Description: Cell Biology|Staining Solution |
SDS-PAGE Staining Solution |
|||
GR103068 | Genorise Scientific | 100 mL | EUR 58 |
Ponceau S Staining Solution |
|||
PW005 | Bio Basic | 100ml | EUR 82.97 |
Ponceau S Staining Solution |
|||
MBS355693-100mL | MyBiosource | 100mL | EUR 180 |
Ponceau S Staining Solution |
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MBS355693-5x100mL | MyBiosource | 5x100mL | EUR 500 |
Sirius Red Staining Solution |
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MBS355815-100mL | MyBiosource | 100mL | EUR 195 |
Sirius Red Staining Solution |
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MBS355815-5x100mL | MyBiosource | 5x100mL | EUR 570 |
AO/PI Double Staining Kit |
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K2238-100 | ApexBio | 100T | EUR 40 |
Description: Cell Biology|Cell Apoptosis |
AO/PI Double Staining Kit |
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K2238-500 | ApexBio | 500T | EUR 120 |
Description: Cell Biology|Cell Apoptosis |
Neutral Red Staining Solution |
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K1185-100 | ApexBio | 100ml | EUR 40 |
Description: Cell Biology|Staining Solution |
EasyDip Slide Staining System |
|||
M900-12AS-ASSORTED | ScyTek Laboratories | 1 Case(s) | EUR 101.58 |
CellSurface FLOW Staining Kit |
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MBS668926-1Kit | MyBiosource | 1Kit | EUR 200 |
CellSurface FLOW Staining Kit |
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MBS668926-5x1Kit | MyBiosource | 5x1Kit | EUR 900 |
Propidium Iodide (PI) Staining Kit |
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abx097208-100l | Abbexa | 100 µl | EUR 162.5 |
Propidium Iodide (PI) Staining Kit |
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abx097208-1ml | Abbexa | 1 ml | Ask for price |
Propidium Iodide (PI) Staining Kit |
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abx097208-200l | Abbexa | 200 µl | Ask for price |
Dual- Color AP Staining Kit |
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AP100D-1 | SBI | 100 Assays | EUR 494.4 |
Coomassie Blue Protein Staining Solution |
|||
abx299720-100g | Abbexa | 100 µg | Ask for price |
Coomassie Blue Protein Staining Solution |
|||
abx299720-20g | Abbexa | 20 µg | EUR 262.5 |
Coomassie Blue Protein Staining Solution |
|||
abx299720-50g | Abbexa | 50 µg | Ask for price |
CometAssay Silver Staining Kit |
|||
4254-200-K | Biotechne | 200 Tests | EUR 390.96 |
PI Viability Staining Solution |
|||
E16FXP002 | EnoGene | 150 tests | EUR 40 |
Description: Available in various conjugation types. |
β-Galactosidase Staining Kit |
|||
AKR-100 | Cell Biolabs | 1 kit | EUR 345 |