Restoration of neuronal connectivity after a lesion of the central nervous system, such as spinal cord injury, is one of the greatest challenges in modern medicine. In particular, the accumulation of factors inhibiting the growth of axons at the site of injury is a major obstacle to the improvement of structural and thus functional.
We previously investigated prenylflavonoids group derived from hops to their capacity to promote neuroregeneration. We identified a molecule called ENDF1 a very powerful tool to increase the re-growth and branching of neurites of dorsal root ganglion neurons in culture in promoting the growth substrate.
In this study, we investigated the capacity ENDF1 to promote regeneration of rat dorsal root ganglion neurons in vitro in the presence of the three main components of the extracellular matrix that acts as an inhibitor of axon growth: semaphorin 3A, Ephrin A4 and mixed with chondroitin sulfate proteoglycans. We reported that ENDF1 application significantly promoted the percentage of sensory neurons were able to regrow their neurites irrespective of their presence inhibitor, and this to an extent similar to that obtained after NGF treatment. In addition, the greatly enhanced ENDF1 total neurite length and complexity of neurites extending from neurons challenged with axon growth inhibitors.
Although the effects of NGF and ENDF1 on regeneration of neurons was similar, ENDF1 activity is not mediated by signaling through TrkA receptor, suggesting that each molecule acts via different signaling pathways. Additionally, ENDF1 not degrade cofilin phosphorylation, downstream effectors associated regeneration of RhoA / ROCK signaling pathway. Therefore, ENDF1 is pro-neuroregenerative potent factor that may help in identifying new efficient targets for regenerative therapies of the nervous system.
Mouse to Mouse HRP (DAB) Staining System |
|||
MTM001 | ScyTek Laboratories | 70 Slides | EUR 157 |
SensiTek HRP Anti-Mouse (DAB) Staining System |
|||
AEA080 | ScyTek Laboratories | 70 Slides | EUR 119 |
SensiTek HRP Anti-Rabbit (DAB) Staining System |
|||
AEI080 | ScyTek Laboratories | 70 Slides | EUR 119 |
SensiTek HRP Anti-Polyvalent (DAB) Staining System |
|||
AEM080 | ScyTek Laboratories | 70 Slides | EUR 127 |
UltraTek HRP Anti-Mouse (DAB) Staining System |
|||
AKA080 | ScyTek Laboratories | 70 Slides | EUR 127 |
UltraTek HRP Anti-Rabbit (DAB) Staining System |
|||
AKC080 | ScyTek Laboratories | 70 Slides | EUR 127 |
UltraTek HRP Anti-Polyvalent (DAB) Staining System |
|||
AMF080 | ScyTek Laboratories | 70 Slides | EUR 138 |
Black-DAB Substrate/Chromogen System for IHC-HRP staining (stable), 30ml |
|||
NB319-SBB | Innovex | 30 ml | EUR 369 |
DAB |
|||
HY-15912 | MedChemExpress | 500mg | EUR 108 |
Black-DAB Substrate/Chromogen System for IHC-HRP staining (stable), 70ml NEW |
|||
NB319-BB70 | Innovex | 70 ml | EUR 485 |
Fmoc-Dab[Fmoc-Dab(Boc)]-OH |
|||
5-04727 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab[Fmoc-Dab(Boc)]-OH |
|||
5-04728 | CHI Scientific | 25g | Ask for price |
STAT-Q Rabbit DAB KIT for staining all Rabbit antibodies, 350 plus slides |
|||
NB314KLRD-20 | Innovex | 20 ml kit | EUR 717 |
DAB Tablet |
|||
D3225-020 | GenDepot | 20TB | EUR 142 |
DAB Tablet |
|||
D3225-050 | GenDepot | 50TB | EUR 246 |
STAT-Q Goat DAB KIT for staining all Goat primary antibodies, 350 plus slides |
|||
NB314KLGD-20 | Innovex | 20 ml kit | EUR 717 |
DAB Chromogen Concentrate |
|||
D3226-002 | GenDepot | 20ml | EUR 161 |
DAB Chromogen Concentrate |
|||
D3226-005 | GenDepot | 50ml | EUR 334 |
Boc-Dab-OH |
|||
A-3215.0001 | Bachem | 1.0g | EUR 126 |
Description: Sum Formula: C9H18N2O4; CAS# [25691-37-6] |
Boc-Dab-OH |
|||
A-3215.0005 | Bachem | 5.0g | EUR 418 |
Description: Sum Formula: C9H18N2O4; CAS# [25691-37-6] |
Boc-Dab-OH |
|||
A-3215.0025 | Bachem | 25.0g | EUR 1578 |
Description: Sum Formula: C9H18N2O4; CAS# [25691-37-6] |
H-Dab-OH·HCl |
|||
5-04703 | CHI Scientific | 5g | Ask for price |
H-Dab-OH·HCl |
|||
5-04704 | CHI Scientific | 25g | Ask for price |
Boc-Dab-OH |
|||
5-04711 | CHI Scientific | 5g | Ask for price |
Boc-Dab-OH |
|||
5-04712 | CHI Scientific | 25g | Ask for price |
Fmoc-Dab-OAll·HCl |
|||
5-04720 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab-OH·HCl |
|||
5-04721 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab-OH·HCl |
|||
5-04722 | CHI Scientific | 25g | Ask for price |
Fmoc-Dab-OH |
|||
5-04735 | CHI Scientific | 1g | Ask for price |
Fmoc-Dab-OH |
|||
5-04736 | CHI Scientific | 5g | Ask for price |
DAB Substrate kit |
|||
30015 | Biotium | 1Kit | EUR 143 |
Description: Minimum order quantity: 1 unit of 1Kit |
DAB Chromogen Kit |
|||
abx097197-1Kit | Abbexa | 1 Kit | EUR 272 |
H-Dab-OH |
|||
F-3050.0001 | Bachem | 1.0g | EUR 115 |
Description: Sum Formula: C4H10N2O2; CAS# [1883-09-6] |
H-Dab-OH |
|||
F-3050.0005 | Bachem | 5.0g | EUR 225 |
Description: Sum Formula: C4H10N2O2; CAS# [1883-09-6] |
H-Dab-OH |
|||
F-3050.0025 | Bachem | 25.0g | EUR 803 |
Description: Sum Formula: C4H10N2O2; CAS# [1883-09-6] |
Z-Dab-OH |
|||
C-3705.0001 | Bachem | 1.0g | EUR 115 |
Description: Sum Formula: C12H16N2O4; CAS# [62234-40-6] |
Z-Dab-OH |
|||
C-3705.0005 | Bachem | 5.0g | EUR 273 |
Description: Sum Formula: C12H16N2O4; CAS# [62234-40-6] |
Z-Dab-OH |
|||
C-3705.0025 | Bachem | 25.0g | EUR 998 |
Description: Sum Formula: C12H16N2O4; CAS# [62234-40-6] |
Fmoc-Dab-OH |
|||
B-2300.0001 | Bachem | 1.0g | EUR 151 |
Description: Sum Formula: C19H20N2O4; CAS# [161420-87-7] |
Fmoc-Dab-OH |
|||
B-2300.0005 | Bachem | 5.0g | EUR 515 |
Description: Sum Formula: C19H20N2O4; CAS# [161420-87-7] |
DAB Chromogen, 4ml |
|||
NB314D | Innovex | 4 ml | EUR 246 |
DL-Dab.2HCl |
|||
A6727-100000 | ApexBio | 100 g | EUR 569 |
Description: DL-Dab.2HCl |
DL-Dab.2HCl |
|||
A6727-25000 | ApexBio | 25 g | EUR 309 |
Description: DL-Dab.2HCl |
DL-Dab.2HCl |
|||
A6727-5000 | ApexBio | 5 g | EUR 180 |
Description: DL-Dab.2HCl |
DAB Chromogen Concentrate |
|||
ACB030 | ScyTek Laboratories | 30 ml | EUR 119 |
DAB Chromogen Concentrate |
|||
ACB060 | ScyTek Laboratories | 60 ml | EUR 165 |
DAB Chromogen Concentrate |
|||
ACB125 | ScyTek Laboratories | 125 ml | EUR 245 |
DAB Chromogen Concentrate |
|||
ACB500 | ScyTek Laboratories | 500 ml | EUR 671 |
DAB Chromogen Concentrate |
|||
ACB999 | ScyTek Laboratories | 1000 ml | EUR 1159 |
DAB Substrate Buffer |
|||
ACC500 | ScyTek Laboratories | 500 ml | EUR 72 |
DAB Substrate Buffer |
|||
ACC999 | ScyTek Laboratories | 1000 ml | EUR 80 |
DAB Enhancer Solution |
|||
ACM030 | ScyTek Laboratories | 30 ml | EUR 71 |
DAB Away Kit |
|||
ACP001 | ScyTek Laboratories | 500 ml | EUR 98 |
DAB Differentiating Solution |
|||
DDS500 | ScyTek Laboratories | 500 ml | EUR 109 |
?-Galactosidase Staining Kit |
|||
AKR-100 | Cell Biolabs | 1 kit | EUR 432 |
Description: This simple assay measures the transfection efficiency of the LacZ gene using a simple staining protocol. |
DAPI Staining Kit |
|||
abx097206-1Kit | Abbexa | 1 Kit | EUR 230 |
PI Staining Kit |
|||
abx097208-1Kit | Abbexa | 1 Kit | EUR 230 |
Sensitive DAB Stain Kit |
|||
PW023 | Bio Basic | 5Preps, 5prep | EUR 69.14 |
H-Dab(Boc)-OH |
|||
A-3305.0001 | Bachem | 1.0g | EUR 200 |
Description: Sum Formula: C9H18N2O4; CAS# [10270-94-7] |
H-Dab(Boc)-OH |
|||
A-3305.0005 | Bachem | 5.0g | EUR 696 |
Description: Sum Formula: C9H18N2O4; CAS# [10270-94-7] |
Boc-Dab(Fmoc)-OH |
|||
A-3520.0001 | Bachem | 1.0g | EUR 225 |
Description: Sum Formula: C24H28N2O6; CAS# [117106-21-5] |
Boc-Dab(Fmoc)-OH |
|||
A-3520.0005 | Bachem | 5.0g | EUR 780 |
Description: Sum Formula: C24H28N2O6; CAS# [117106-21-5] |
Boc-Dab(Aloc)-OH |
|||
A-4125.0001 | Bachem | 1.0g | EUR 309 |
Description: Sum Formula: C13H22N2O6; CAS# [171820-73-8] |
Boc-Dab(Aloc)-OH |
|||
A-4125.0005 | Bachem | 5.0g | EUR 1143 |
Description: Sum Formula: C13H22N2O6; CAS# [171820-73-8] |
Boc-D-Dab-OH |
|||
A-4215.0001 | Bachem | 1.0g | EUR 418 |
Description: Sum Formula: C9H18N2O4; CAS# [80445-78-9] |
Boc-D-Dab-OH |
|||
A-4215.0005 | Bachem | 5.0g | EUR 1554 |
Description: Sum Formula: C9H18N2O4; CAS# [80445-78-9] |
Boc-Dab-OtBu · HCl |
|||
A-4415.0001 | Bachem | 1.0g | EUR 309 |
Description: Sum Formula: C13H26N2O4·HCl; CAS# [190447-69-9] net |
Boc-Dab-OtBu · HCl |
|||
A-4415.0005 | Bachem | 5.0g | EUR 1143 |
Description: Sum Formula: C13H26N2O4·HCl; CAS# [190447-69-9] net |
H-Dab(Z)-OH |
|||
5-04707 | CHI Scientific | 5g | Ask for price |
H-Dab(Z)-OH |
|||
5-04708 | CHI Scientific | 25g | Ask for price |
Boc-Dab(Boc)-OH·DCHA |
|||
5-04713 | CHI Scientific | 1g | Ask for price |
Boc-Dab(Boc)-OH·DCHA |
|||
5-04714 | CHI Scientific | 5g | Ask for price |
Boc-Dab(Fmoc)-OH |
|||
5-04715 | CHI Scientific | 5g | Ask for price |
Boc-Dab(Fmoc)-OH |
|||
5-04716 | CHI Scientific | 25g | Ask for price |
Boc-Dab(Z)-OH·DCHA |
|||
5-04717 | CHI Scientific | 5g | Ask for price |
Boc-Dab(Z)-OH·DCHA |
|||
5-04718 | CHI Scientific | 25g | Ask for price |
Fmoc-Dab(Ac)-OH |
|||
5-04723 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab(Ac)-OH |
|||
5-04724 | CHI Scientific | 25g | Ask for price |
Fmoc-Dab(Boc)-OH |
|||
5-04725 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab(Boc)-OH |
|||
5-04726 | CHI Scientific | 25g | Ask for price |
Fmoc-Dab(Fmoc)-OH |
|||
5-04729 | CHI Scientific | 1g | Ask for price |
Fmoc-Dab(Fmoc)-OH |
|||
5-04730 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab(MMt)-OH |
|||
5-04731 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab(MMt)-OH |
|||
5-04732 | CHI Scientific | 25g | Ask for price |
Fmoc-Dab(Mtt)-OH |
|||
5-04733 | CHI Scientific | 1g | Ask for price |
Fmoc-Dab(Mtt)-OH |
|||
5-04734 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab(Dde)-OH |
|||
5-04739 | CHI Scientific | 1g | Ask for price |
Fmoc-Dab(Dde)-OH |
|||
5-04740 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab(ivDde)-OH |
|||
5-04741 | CHI Scientific | 1g | Ask for price |
Fmoc-Dab(ivDde)-OH |
|||
5-04742 | CHI Scientific | 5g | Ask for price |
Fmoc-Dab(Z)-OH |
|||
5-04743 | CHI Scientific | 1g | Ask for price |
Fmoc-Dab(Z)-OH |
|||
5-04744 | CHI Scientific | 5g | Ask for price |
Boc-D-Dab-OH |
|||
5-04745 | CHI Scientific | 1g | Ask for price |
Boc-D-Dab-OH |
|||
5-04746 | CHI Scientific | 5g | Ask for price |
Fmoc-D-Dab-OH |
|||
5-04751 | CHI Scientific | 1g | Ask for price |
Fmoc-D-Dab-OH |
|||
5-04752 | CHI Scientific | 5g | Ask for price |