The Prenylflavonoid ENDF1 Overrules Central Nervous System Growth Inhibitors and Facilitates Regeneration of DRG Neurons.

Restoration of neuronal connectivity after a lesion of the central nervous system, such as spinal cord injury, is one of the greatest challenges in modern medicine. In particular, the accumulation of factors inhibiting the growth of axons at the site of injury is a major obstacle to the improvement of structural and thus functional.

We previously investigated prenylflavonoids group derived from hops to their capacity to promote neuroregeneration. We identified a molecule called ENDF1 a very powerful tool to increase the re-growth and branching of neurites of dorsal root ganglion neurons in culture in promoting the growth substrate.

In this study, we investigated the capacity ENDF1 to promote regeneration of rat dorsal root ganglion neurons in vitro in the presence of the three main components of the extracellular matrix that acts as an inhibitor of axon growth: semaphorin 3A, Ephrin A4 and mixed with chondroitin sulfate proteoglycans. We reported that ENDF1 application significantly promoted the percentage of sensory neurons were able to regrow their neurites irrespective of their presence inhibitor, and this to an extent similar to that obtained after NGF treatment. In addition, the greatly enhanced ENDF1 total neurite length and complexity of neurites extending from neurons challenged with axon growth inhibitors.

Although the effects of NGF and ENDF1 on regeneration of neurons was similar, ENDF1 activity is not mediated by signaling through TrkA receptor, suggesting that each molecule acts via different signaling pathways. Additionally, ENDF1 not degrade cofilin phosphorylation, downstream effectors associated regeneration of RhoA / ROCK signaling pathway. Therefore, ENDF1 is pro-neuroregenerative potent factor that may help in identifying new efficient targets for regenerative therapies of the nervous system.

Mouse to Mouse HRP (DAB) Staining System
MTM001	ScyTek Laboratories	70 Slides	EUR 157

SensiTek HRP Anti-Mouse (DAB) Staining System
AEA080	ScyTek Laboratories	70 Slides	EUR 119

SensiTek HRP Anti-Rabbit (DAB) Staining System
AEI080	ScyTek Laboratories	70 Slides	EUR 119

SensiTek HRP Anti-Polyvalent (DAB) Staining System
AEM080	ScyTek Laboratories	70 Slides	EUR 127

UltraTek HRP Anti-Mouse (DAB) Staining System
AKA080	ScyTek Laboratories	70 Slides	EUR 127

UltraTek HRP Anti-Rabbit (DAB) Staining System
AKC080	ScyTek Laboratories	70 Slides	EUR 127

UltraTek HRP Anti-Polyvalent (DAB) Staining System
AMF080	ScyTek Laboratories	70 Slides	EUR 138

Black-DAB Substrate/Chromogen System for IHC-HRP staining (stable), 30ml
NB319-SBB	Innovex	30 ml	EUR 369

DAB
HY-15912	MedChemExpress	500mg	EUR 108

Black-DAB Substrate/Chromogen System for IHC-HRP staining (stable), 70ml NEW
NB319-BB70	Innovex	70 ml	EUR 485

Fmoc-Dab[Fmoc-Dab(Boc)]-OH
5-04727	CHI Scientific	5g	Ask for price

Fmoc-Dab[Fmoc-Dab(Boc)]-OH
5-04728	CHI Scientific	25g	Ask for price

STAT-Q Rabbit DAB KIT for staining all Rabbit antibodies, 350 plus slides
NB314KLRD-20	Innovex	20 ml kit	EUR 717

DAB Tablet
D3225-020	GenDepot	20TB	EUR 142

DAB Tablet
D3225-050	GenDepot	50TB	EUR 246

STAT-Q Goat DAB KIT for staining all Goat primary antibodies, 350 plus slides
NB314KLGD-20	Innovex	20 ml kit	EUR 717

DAB Chromogen Concentrate
D3226-002	GenDepot	20ml	EUR 161

DAB Chromogen Concentrate
D3226-005	GenDepot	50ml	EUR 334

Boc-Dab-OH
A-3215.0001	Bachem	1.0g	EUR 126
Description: Sum Formula: C9H18N2O4; CAS# [25691-37-6]

Boc-Dab-OH
A-3215.0005	Bachem	5.0g	EUR 418
Description: Sum Formula: C9H18N2O4; CAS# [25691-37-6]

Boc-Dab-OH
A-3215.0025	Bachem	25.0g	EUR 1578
Description: Sum Formula: C9H18N2O4; CAS# [25691-37-6]

H-Dab-OH·HCl
5-04703	CHI Scientific	5g	Ask for price

H-Dab-OH·HCl
5-04704	CHI Scientific	25g	Ask for price

Boc-Dab-OH
5-04711	CHI Scientific	5g	Ask for price

Boc-Dab-OH
5-04712	CHI Scientific	25g	Ask for price

Fmoc-Dab-OAll·HCl
5-04720	CHI Scientific	5g	Ask for price

Fmoc-Dab-OH·HCl
5-04721	CHI Scientific	5g	Ask for price

Fmoc-Dab-OH·HCl
5-04722	CHI Scientific	25g	Ask for price

Fmoc-Dab-OH
5-04735	CHI Scientific	1g	Ask for price

Fmoc-Dab-OH
5-04736	CHI Scientific	5g	Ask for price

DAB Substrate kit
30015	Biotium	1Kit	EUR 143
Description: Minimum order quantity: 1 unit of 1Kit

DAB Chromogen Kit
abx097197-1Kit	Abbexa	1 Kit	EUR 272

H-Dab-OH
F-3050.0001	Bachem	1.0g	EUR 115
Description: Sum Formula: C4H10N2O2; CAS# [1883-09-6]

H-Dab-OH
F-3050.0005	Bachem	5.0g	EUR 225
Description: Sum Formula: C4H10N2O2; CAS# [1883-09-6]

H-Dab-OH
F-3050.0025	Bachem	25.0g	EUR 803
Description: Sum Formula: C4H10N2O2; CAS# [1883-09-6]

Z-Dab-OH
C-3705.0001	Bachem	1.0g	EUR 115
Description: Sum Formula: C12H16N2O4; CAS# [62234-40-6]

Z-Dab-OH
C-3705.0005	Bachem	5.0g	EUR 273
Description: Sum Formula: C12H16N2O4; CAS# [62234-40-6]

Z-Dab-OH
C-3705.0025	Bachem	25.0g	EUR 998
Description: Sum Formula: C12H16N2O4; CAS# [62234-40-6]

Fmoc-Dab-OH
B-2300.0001	Bachem	1.0g	EUR 151
Description: Sum Formula: C19H20N2O4; CAS# [161420-87-7]

Fmoc-Dab-OH
B-2300.0005	Bachem	5.0g	EUR 515
Description: Sum Formula: C19H20N2O4; CAS# [161420-87-7]

DAB Chromogen, 4ml
NB314D	Innovex	4 ml	EUR 246

DL-Dab.2HCl
A6727-100000	ApexBio	100 g	EUR 569
Description: DL-Dab.2HCl

DL-Dab.2HCl
A6727-25000	ApexBio	25 g	EUR 309
Description: DL-Dab.2HCl

DL-Dab.2HCl
A6727-5000	ApexBio	5 g	EUR 180
Description: DL-Dab.2HCl

DAB Chromogen Concentrate
ACB030	ScyTek Laboratories	30 ml	EUR 119

DAB Chromogen Concentrate
ACB060	ScyTek Laboratories	60 ml	EUR 165

DAB Chromogen Concentrate
ACB125	ScyTek Laboratories	125 ml	EUR 245

DAB Chromogen Concentrate
ACB500	ScyTek Laboratories	500 ml	EUR 671

DAB Chromogen Concentrate
ACB999	ScyTek Laboratories	1000 ml	EUR 1159

DAB Substrate Buffer
ACC500	ScyTek Laboratories	500 ml	EUR 72

DAB Substrate Buffer
ACC999	ScyTek Laboratories	1000 ml	EUR 80

DAB Enhancer Solution
ACM030	ScyTek Laboratories	30 ml	EUR 71

DAB Away Kit
ACP001	ScyTek Laboratories	500 ml	EUR 98

DAB Differentiating Solution
DDS500	ScyTek Laboratories	500 ml	EUR 109

?-Galactosidase Staining Kit
AKR-100	Cell Biolabs	1 kit	EUR 432
Description: This simple assay measures the transfection efficiency of the LacZ gene using a simple staining protocol.

DAPI Staining Kit
abx097206-1Kit	Abbexa	1 Kit	EUR 230

PI Staining Kit
abx097208-1Kit	Abbexa	1 Kit	EUR 230

Sensitive DAB Stain Kit
PW023	Bio Basic	5Preps, 5prep	EUR 69.14

H-Dab(Boc)-OH
A-3305.0001	Bachem	1.0g	EUR 200
Description: Sum Formula: C9H18N2O4; CAS# [10270-94-7]

H-Dab(Boc)-OH
A-3305.0005	Bachem	5.0g	EUR 696
Description: Sum Formula: C9H18N2O4; CAS# [10270-94-7]

Boc-Dab(Fmoc)-OH
A-3520.0001	Bachem	1.0g	EUR 225
Description: Sum Formula: C24H28N2O6; CAS# [117106-21-5]

Boc-Dab(Fmoc)-OH
A-3520.0005	Bachem	5.0g	EUR 780
Description: Sum Formula: C24H28N2O6; CAS# [117106-21-5]

Boc-Dab(Aloc)-OH
A-4125.0001	Bachem	1.0g	EUR 309
Description: Sum Formula: C13H22N2O6; CAS# [171820-73-8]

Boc-Dab(Aloc)-OH
A-4125.0005	Bachem	5.0g	EUR 1143
Description: Sum Formula: C13H22N2O6; CAS# [171820-73-8]

Boc-D-Dab-OH
A-4215.0001	Bachem	1.0g	EUR 418
Description: Sum Formula: C9H18N2O4; CAS# [80445-78-9]

Boc-D-Dab-OH
A-4215.0005	Bachem	5.0g	EUR 1554
Description: Sum Formula: C9H18N2O4; CAS# [80445-78-9]

Boc-Dab-OtBu · HCl
A-4415.0001	Bachem	1.0g	EUR 309
Description: Sum Formula: C13H26N2O4·HCl; CAS# [190447-69-9] net

Boc-Dab-OtBu · HCl
A-4415.0005	Bachem	5.0g	EUR 1143
Description: Sum Formula: C13H26N2O4·HCl; CAS# [190447-69-9] net

H-Dab(Z)-OH
5-04707	CHI Scientific	5g	Ask for price

H-Dab(Z)-OH
5-04708	CHI Scientific	25g	Ask for price

Boc-Dab(Boc)-OH·DCHA
5-04713	CHI Scientific	1g	Ask for price

Boc-Dab(Boc)-OH·DCHA
5-04714	CHI Scientific	5g	Ask for price

Boc-Dab(Fmoc)-OH
5-04715	CHI Scientific	5g	Ask for price

Boc-Dab(Fmoc)-OH
5-04716	CHI Scientific	25g	Ask for price

Boc-Dab(Z)-OH·DCHA
5-04717	CHI Scientific	5g	Ask for price

Boc-Dab(Z)-OH·DCHA
5-04718	CHI Scientific	25g	Ask for price

Fmoc-Dab(Ac)-OH
5-04723	CHI Scientific	5g	Ask for price

Fmoc-Dab(Ac)-OH
5-04724	CHI Scientific	25g	Ask for price

Fmoc-Dab(Boc)-OH
5-04725	CHI Scientific	5g	Ask for price

Fmoc-Dab(Boc)-OH
5-04726	CHI Scientific	25g	Ask for price

Fmoc-Dab(Fmoc)-OH
5-04729	CHI Scientific	1g	Ask for price

Fmoc-Dab(Fmoc)-OH
5-04730	CHI Scientific	5g	Ask for price

Fmoc-Dab(MMt)-OH
5-04731	CHI Scientific	5g	Ask for price

Fmoc-Dab(MMt)-OH
5-04732	CHI Scientific	25g	Ask for price

Fmoc-Dab(Mtt)-OH
5-04733	CHI Scientific	1g	Ask for price

Fmoc-Dab(Mtt)-OH
5-04734	CHI Scientific	5g	Ask for price

Fmoc-Dab(Dde)-OH
5-04739	CHI Scientific	1g	Ask for price

Fmoc-Dab(Dde)-OH
5-04740	CHI Scientific	5g	Ask for price

Fmoc-Dab(ivDde)-OH
5-04741	CHI Scientific	1g	Ask for price

Fmoc-Dab(ivDde)-OH
5-04742	CHI Scientific	5g	Ask for price

Fmoc-Dab(Z)-OH
5-04743	CHI Scientific	1g	Ask for price

Fmoc-Dab(Z)-OH
5-04744	CHI Scientific	5g	Ask for price

Boc-D-Dab-OH
5-04745	CHI Scientific	1g	Ask for price

Boc-D-Dab-OH
5-04746	CHI Scientific	5g	Ask for price

Fmoc-D-Dab-OH
5-04751	CHI Scientific	1g	Ask for price

Fmoc-D-Dab-OH
5-04752	CHI Scientific	5g	Ask for price

Fmoc-Dab(Fmoc)-Oh
abx188721-250g	Abbexa	250 g	EUR 1720

Ac-Dab(Boc)-OH
F-1020.0250	Bachem	250.0mg	EUR 236
Description: Sum Formula: C11H20N2O5; CAS# [201351-32-8]

Ac-Dab(Boc)-OH
F-1020.1000	Bachem	1.0g	EUR 660
Description: Sum Formula: C11H20N2O5; CAS# [201351-32-8]

H-D-Dab-OH
F-3055.0001	Bachem	1.0g	EUR 225
Description: Sum Formula: C4H10N2O2; CAS# [26908-94-1] net

H-D-Dab-OH
F-3055.0005	Bachem	5.0g	EUR 792
Description: Sum Formula: C4H10N2O2; CAS# [26908-94-1] net

Z-Dab(Z)-OH
C-3690.0001	Bachem	1.0g	EUR 200
Description: Sum Formula: C20H22N2O6; CAS# [55478-23-4]

Z-Dab(Z)-OH
C-3690.0005	Bachem	5.0g	EUR 696
Description: Sum Formula: C20H22N2O6; CAS# [55478-23-4]

Z-D-Dab-OH
C-3770.0001	Bachem	1.0g	EUR 225
Description: Sum Formula: C12H16N2O4; CAS# [70882-66-5]

Z-D-Dab-OH
C-3770.0005	Bachem	5.0g	EUR 792
Description: Sum Formula: C12H16N2O4; CAS# [70882-66-5]

Fmoc-Dab(Boc)-OH
B-1800.0001	Bachem	1.0g	EUR 200
Description: Sum Formula: C24H28N2O6; CAS# [125238-99-5]

Fmoc-Dab(Boc)-OH
B-1800.0005	Bachem	5.0g	EUR 683
Description: Sum Formula: C24H28N2O6; CAS# [125238-99-5]

Fmoc-Dab(Fmoc)-OH
B-2270.0001	Bachem	1.0g	EUR 236
Description: Sum Formula: C34H30N2O6; CAS# [201473-83-8]

Fmoc-Dab(Fmoc)-OH
B-2270.0005	Bachem	5.0g	EUR 866
Description: Sum Formula: C34H30N2O6; CAS# [201473-83-8]

Fmoc-D-Dab-OH
B-2365.0001	Bachem	1.0g	EUR 418
Description: Sum Formula: C19H20N2O4; CAS# [201484-12-0]

Fmoc-D-Dab-OH
B-2365.0005	Bachem	5.0g	EUR 1554
Description: Sum Formula: C19H20N2O4; CAS# [201484-12-0]

Fmoc-Dab(Aloc)-OH
B-2850.0001	Bachem	1.0g	EUR 297
Description: Sum Formula: C23H24N2O6; CAS# [204316-32-5]

Fmoc-Dab(Aloc)-OH
B-2850.0005	Bachem	5.0g	EUR 1106
Description: Sum Formula: C23H24N2O6; CAS# [204316-32-5]

Fmoc-Dab(Z)-OH
B-3250.0001	Bachem	1.0g	EUR 261
Description: Sum Formula: C27H26N2O6; CAS# [252049-08-4]

Fmoc-Dab(Z)-OH
B-3250.0005	Bachem	5.0g	EUR 925
Description: Sum Formula: C27H26N2O6; CAS# [252049-08-4]

Fmoc-Dab(ivDde)-OH
B-4065.0001	Bachem	1.0g	EUR 297
Description: Sum Formula: C32H38N2O6; CAS# [607366-21-2]

Fmoc-Dab(ivDde)-OH
B-4065.0005	Bachem	5.0g	EUR 1093
Description: Sum Formula: C32H38N2O6; CAS# [607366-21-2]

DAB Substrate buffer, 70ml
NB314SB	Innovex	70 ml	EUR 276

DAB Chromogen/Substrate Kit
ACH500	ScyTek Laboratories	500 Slides	EUR 85

DAB Substrate (High Contrast)
ACU250	ScyTek Laboratories	250 ml	EUR 85

DAB Substrate (High Contrast)
ACU500	ScyTek Laboratories	500 ml	EUR 98

DAB Substrate (High Contrast)
ACU999	ScyTek Laboratories	1000 ml	EUR 119

10-DAB (10-Deacetylbaccatin)
A4395-25	ApexBio	25 mg	EUR 514
Description: 10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus.

10-DAB (10-Deacetylbaccatin)
A4395-5	ApexBio	5 mg	EUR 166
Description: 10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus.

10-DAB (10-Deacetylbaccatin)
A4395-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 293
Description: 10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus.

10-DAB (10-Deacetylbaccatin)
A4395-S	ApexBio	Evaluation Sample	EUR 81
Description: 10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus.

DAB (Post) Enhancing Solution
DES500	ScyTek Laboratories	500 ml	EUR 88

DAB (Post) Enhancing Solution
DES999	ScyTek Laboratories	1000 ml	EUR 109

Ponceau S Staining Solution
PW005	Bio Basic	100ml	EUR 69.14

ProsiBlue Gel Staining Solution
P7300-050	GenDepot	500ml	EUR 174

PI / RNase Staining Buffer
20-abx090619	Abbexa	EUR 272.00 EUR 230.00	100 tests 50 tests

Hoechst 33342 Staining Kit
abx097207-1Kit	Abbexa	1 Kit	EUR 230

Human Histochemistry Staining Kit
20-abx299039	Abbexa	EUR 871.00 EUR 1219.00 EUR 565.00	150 tests 500 tests 50 tests

CometAssay Silver Staining Kit
4254-200-K	Biotechne	200 Tests	EUR 325.8

Beta-Galactosidase Staining Kit
K2182-250	ApexBio	250 assays	EUR 293

EasyDip Slide Staining System
M900-12AS-ASSORTED	ScyTek Laboratories	1 Case(s)	EUR 176

Ponceau S Staining Solution
B7778-100000	ApexBio	100 g	EUR 163

Ponceau S Staining Solution
B7778-50000	ApexBio	50 g	EUR 126

Beta Galactosidase Staining Kit
55R-1541	Fitzgerald	250 assays	EUR 370
Description: Assay Kit for detection of Beta Galactosidase in the research laboratory

SDS-PAGE Staining Solution
GR103068	Genorise Scientific	100 mL	EUR 58

Alkaline Phosphatase Staining Kit
K2035-50	Biovision	50 assays	EUR 379

Beta-Galactosidase Staining Kit
K802-250	Biovision		EUR 294

STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 1000 plus slides (large size kit)
NB314KLD	Innovex	1000 slides	EUR 1030

STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 350 slides kit (small size Kit)
NB314KLD-20	Innovex	300 slide kit	EUR 682

Boc-Dab(Z)-OH · DCHA
A-2905.0001	Bachem	1.0g	EUR 126
Description: Sum Formula: C17H24N2O6·C12H23N; CAS# [16947-89-0]

Boc-Dab(Z)-OH · DCHA
A-2905.0005	Bachem	5.0g	EUR 393
Description: Sum Formula: C17H24N2O6·C12H23N; CAS# [16947-89-0]

Boc-Dab(Boc)-OH · DCHA
A-3480.0001	Bachem	1.0g	EUR 176
Description: Sum Formula: C14H26N2O6·C12H23N; CAS# [201472-66-4]

Boc-Dab(Boc)-OH · DCHA
A-3480.0005	Bachem	5.0g	EUR 587
Description: Sum Formula: C14H26N2O6·C12H23N; CAS# [201472-66-4]

Boc-D-Dab(Fmoc)-OH
A-4230.0001	Bachem	1.0g	EUR 393
Description: Sum Formula: C24H28N2O6; CAS# [131570-57-5]

Boc-D-Dab(Fmoc)-OH
A-4230.0005	Bachem	5.0g	EUR 1482
Description: Sum Formula: C24H28N2O6; CAS# [131570-57-5]

Boc-D-Dab(Fmoc)-OH
5-04747	CHI Scientific	5g	Ask for price

Boc-D-Dab(Fmoc)-OH
5-04748	CHI Scientific	25g	Ask for price

Boc-D-Dab(Z)-OH·DCHA
5-04749	CHI Scientific	5g	Ask for price

Boc-D-Dab(Z)-OH·DCHA
5-04750	CHI Scientific	25g	Ask for price

Fmoc-D-Dab(Alloc)-OH
5-04753	CHI Scientific	1g	Ask for price