The Prenylflavonoid ENDF1 Overrules Central Nervous System Growth Inhibitors and Facilitates Regeneration of DRG Neurons.

Restoration of neuronal connectivity after a lesion of the central nervous system, such as spinal cord injury, is one of the greatest challenges in modern medicine. In particular, the accumulation of factors inhibiting the growth of axons at the site of injury is a major obstacle to the improvement of structural and thus functional.

We previously investigated prenylflavonoids group derived from hops to their capacity to promote neuroregeneration. We identified a molecule called ENDF1 a very powerful tool to increase the re-growth and branching of neurites of dorsal root ganglion neurons in culture in promoting the growth substrate.

In this study, we investigated the capacity ENDF1 to promote regeneration of rat dorsal root ganglion neurons in vitro in the presence of the three main components of the extracellular matrix that acts as an inhibitor of axon growth: semaphorin 3A, Ephrin A4 and mixed with chondroitin sulfate proteoglycans. We reported that ENDF1 application significantly promoted the percentage of sensory neurons were able to regrow their neurites irrespective of their presence inhibitor, and this to an extent similar to that obtained after NGF treatment. In addition, the greatly enhanced ENDF1 total neurite length and complexity of neurites extending from neurons challenged with axon growth inhibitors.

Although the effects of NGF and ENDF1 on regeneration of neurons was similar, ENDF1 activity is not mediated by signaling through TrkA receptor, suggesting that each molecule acts via different signaling pathways. Additionally, ENDF1 not degrade cofilin phosphorylation, downstream effectors associated regeneration of RhoA / ROCK signaling pathway. Therefore, ENDF1 is pro-neuroregenerative potent factor that may help in identifying new efficient targets for regenerative therapies of the nervous system.

UltraTek HRP Anti-Rabbit (DAB) Staining System

AKC080 70 Slides
EUR 61.72

SensiTek HRP Anti-Polyvalent (DAB) Staining System

AEM080 70 Slides
EUR 61.72

UltraTek HRP Anti-Polyvalent (DAB) Staining System

AMF080 70 Slides
EUR 70.71

STAT-Q Multivalent DAB KIT for staining Mouse, Rat

NB314KLD 1000 slides
EUR 895
Description: STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 1000 plus slides (Large size kit)

STAT-Q Multivalent DAB KIT for staining Mouse, Rat

NB314KLD-20 300 slide kit
EUR 595
Description: STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 350 slides kit (Small size Kit)

STAT-Q Goat DAB KIT for staining all Goat primary

NB314KLGD-20 20 ml kit
EUR 589
Description: STAT-Q Goat DAB KIT for staining all Goat primary antibodies, 350 plus slides

STAT-Q Rabbit DAB KIT for staining all Rabbit anti

NB314KLRD-20 20 ml kit
EUR 585
Description: STAT-Q Rabbit DAB KIT for staining all Rabbit antibodies, 350 plus slides

STAT-Q Mouse Adsorbed DAB KIT for staining Rat ant

NB314MAK-DAB 200-250 slides
EUR 695
Description: STAT-Q Mouse Adsorbed DAB KIT for staining Rat antibodies-on-Mouse tissues 250 plus slide kit

STAT-Q Rat Adsorbed DAB KIT for staining Mouse ant

NB314RAK-DAB 200-250 slides
EUR 695
Description: STAT-Q Rat Adsorbed DAB KIT for staining Mouse antibodies-on-Rat tissues 250 plus slides kit

STAT Double Staining ragent for Double staining Mo

NB330DB 25 ml
EUR 595
Description: STAT Double Staining ragent for Double staining Mouse and Sheep antibodies, 450 Plus slides

STAT Double Staining reagent for Double staining o

NB326DB 25 ml
EUR 595
Description: STAT Double Staining reagent for Double staining of Mouse and Rabbit antibodies, 450 plus slides

STAT Double Staining Reagent for Double staining o

NB327DB 25 ml
EUR 595
Description: STAT Double Staining Reagent for Double staining of Mouse and Goat antibodies, 450 plus slides

PI Staining Kit

abx097208-1Kit 1 Kit
EUR 276

HE Staining Kit

E-IR-R117-100mL 100mL
EUR 240

HE Staining Kit

E-IR-R117-10mL 10mL
EUR 35

HE Staining Kit

E-IR-R117-50mL 50mL
EUR 150

HE Staining Kit

E-IR-R117-each each Ask for price

DAPI Staining Kit

abx097206-1Kit 1 Kit
EUR 276

TRAP Staining Kit

KT-008 1 kit
EUR 747

DAPI Staining Kit

abx097206-100l 100 µl
EUR 162.5

DAPI Staining Kit

abx097206-1ml 1 ml Ask for price

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Coplin Staining Jar

08415-3 3sets
EUR 84

Silver Staining Kit

ML123-1KT 1 unit
EUR 201.16
Description: Silver Staining Kit

Mitraphyllin - exact weight protocol

M374000 250mg
EUR 1200
Description: 509-80-8

Cell Staining Buffer

E-CK-A107-100mL 100 mL
EUR 20

Cell Staining Buffer

E-CK-A107-200mL 200 mL
EUR 35

Cell Staining Buffer

E-CK-A107-500mL 500 mL
EUR 60

Cell Staining Buffer

E16FXP005 500 ml
EUR 40
Description: Available in various conjugation types.

DNA Staining Reagent

abx299713-100g 100 µg Ask for price

DNA Staining Reagent

abx299713-20g 20 µg
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DNA Staining Reagent

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Cell Staining Buffer

E-CK-A107-each each Ask for price

ELVIS ID Staining Kit

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ELVIS ID Staining Kit

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Hoechst 33342 Staining Kit

abx097207-1Kit 1 Kit
EUR 276

Hoechst 33342 Staining Kit

abx097207-100l 100 µl
EUR 162.5

Hoechst 33342 Staining Kit

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Hoechst 33342 Staining Kit

abx097207-200l 200 µl Ask for price

DNA STAINING AGENT (1ML)

NOVELJUICE each
EUR 80

Cell Cycle Staining Kit

KTA2020-100T 100 T
EUR 119
Description: Abbkine Cell Cycle Staining Kit provides a convenient and accurate determination of the percentage of cells in each phase of the cell cycle.

Cell Cycle Staining Kit

KTA2020-50T 50 T
EUR 69
Description: Abbkine Cell Cycle Staining Kit provides a convenient and accurate determination of the percentage of cells in each phase of the cell cycle.

Cell Cycle Staining Kit

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Hematoxylin Staining Buffer

E-IR-R120-15mL 15mL
EUR 60

Hematoxylin Staining Buffer

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EUR 170

Hematoxylin Staining Buffer

E-IR-R120-5mL 5mL
EUR 25

Hematoxylin Staining Buffer

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Live NucRed staining kit

EGY069 >100T
EUR 210

PI / RNase Staining Buffer

20-abx090619
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PI / RNase Staining Buffer

abx090619-100l 100 µl
EUR 162.5

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PI / RNase Staining Buffer

abx090619-200l 200 µl
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HISTOCHEMISTRY STAINING TRAY

ATC-12 12 PLACE - CLEAR LID
EUR 226.1

HISTOCHEMISTRY STAINING TRAY

ATC-24 24 PLACE - CLEAR LID
EUR 342.21

HISTOCHEMISTRY STAINING TRAY

AT-12 12 PLACE - BLACK LID
EUR 226.1

HISTOCHEMISTRY STAINING TRAY

AT-24 24 PLACE - BLACK LID
EUR 342.21

Exosome fluorescent staining

S104 -
EUR 800

ProsiBlue Gel Staining Solution

P7300-050 500ml
EUR 208.8

Ponceau S Protein Staining Solution

PS003-B500ML 500 ml
EUR 25

Stains All Gel Staining Kit

KT-792 20 tests
EUR 737

Cyflufenamid-d5 - Exact Weight Protocol

C989602 25mg
EUR 12800

Live NucGreen staining kit

EGY068 >100T
EUR 210

Dead NucGreen staining kit

EGY070 >100T
EUR 210

GEL STAINING/INCUBATION BOX

SB-10 LIGHT SHIELDING
EUR 94.44

Ponceau S Staining Solution

41640009-1 500 mL
EUR 40.13

Ponceau S Staining Solution

41640009-2 1 L
EUR 58.16

SDS-PAGE Staining Solution

GR103068 100 mL
EUR 58

Ponceau S Staining Solution

B7778-100000 100 g
EUR 78
Description: Rapid (5 min) staining of protein bands on nitrocellulose or PVDF membranes

Ponceau S Staining Solution

B7778-50000 50 g
EUR 53
Description: Rapid (5 min) staining of protein bands on nitrocellulose or PVDF membranes

Ponceau S Staining Solution

PW005 100ml
EUR 82.97

Ponceau S Staining Solution

EZWB08-1x-100mL 100mL
EUR 9.6

Ponceau S Staining Solution

EZWB08-1x-500mL 500mL
EUR 32.4

Propidium Iodide (PI) Staining Kit

abx097208-100l 100 µl
EUR 162.5

Propidium Iodide (PI) Staining Kit

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Dual- Color AP Staining Kit

AP100D-1 100 Assays
EUR 494.4

Coomassie Blue Protein Staining Solution

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abx299720-20g 20 µg
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EasyDip Slide Staining System

M900-12AS-ASSORTED 1 Case(s)
EUR 101.58

Live/Dead Cell Staining Kit

55R-1434 100 tests
EUR 500
Description: Live/Dead Cell Staining Kit for use in the research laboratory

Red-Color AP Staining Kit

AP100R-1 50 Assays
EUR 314.4

PI Viability Staining Solution

E16FXP002 150 tests
EUR 40
Description: Available in various conjugation types.

CometAssay Silver Staining Kit

4254-200-K 200 Tests
EUR 390.96

β-Galactosidase Staining Kit

AKR-100 1 kit
EUR 345

Methyl Green Staining Solution

abx090698-100l 100 µl
EUR 125

Methyl Green Staining Solution

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Methyl Green Staining Solution

abx090698-200l 200 µl
EUR 187.5

Blue-Color AP Staining Kit

AP100B-1 50 Assays
EUR 203

10X Ponceau S Protein Staining Solution

PS003-L10X 500 ml
EUR 170

Beta Galactosidase Staining Kit

55R-1541 250 assays
EUR 300
Description: Assay Kit for detection of Beta Galactosidase in the research laboratory

Live-Dead Cell Staining Kit

GWB-AXR262 100 stainings Ask for price

Live-Dead Cell Staining Kit

K501-100 each
EUR 561.6

Live-Dead Cell Staining Kit

K2081-100 100 staining
EUR 552

Live-Dead Cell Staining Kit

K2081-1000 1000T
EUR 112

Live-Dead Cell Staining Kit

K2081-500 500T
EUR 68

EZ-Quick Slide Staining Set

IW-2510 -
EUR 425

HiPer® Protein Silver Staining Teaching

HTP002-5PR 1 unit
EUR 65.7
Description: HiPer® Protein Silver Staining Teaching

COOMASSIEnano Protein Staining Solution, 500ml

PS002-B500ML 500 ml
EUR 30

Nerve Terminal Staining Kit I

70030-1 KT
EUR 605

Nerve Terminal Staining Kit V

70034 1SET
EUR 605
Description: N/A

Nerve Terminal Staining Kit V

70034-1 KT
EUR 605

Purple-Color AP Staining Kit

AP100P-1 100 Assays
EUR 235

Human Histochemistry Staining Kit

20-abx299039
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  • 150 tests
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Beta-Galactosidase Staining Kit

GWB-AXR372 200 assays. Ask for price

Alkaline Phosphatase Staining Kit

K2035-50 50 assays
EUR 454.8

Beta-Galactosidase Staining Kit

K2182-250 250 assays
EUR 274

Beta-Galactosidase Staining Kit

K802-250 each
EUR 352.8

Slides Staining Jar, Schifferdecker

CG146-5X1NO 1 unit
EUR 53.59
Description: Slides Staining Jar, Schifferdecker

Lipid (Oil Red O) staining Kit

K580-24 each
EUR 542.4

Nerve Terminal Staining Kit IIA

70031-1 1SET
EUR 322
Description: N/A

Nerve Terminal Staining Kit IIB

70031-1-1 KT
EUR 395

Nerve Terminal Staining Kit III

70032-1 KT
EUR 513

Red Active Caspase Staining Kit

K2052-100 100 assays
EUR 418
Description: Detects activated Caspases by FACS, FL or plate reader

Red Active Caspase Staining Kit

K2052-25 25 assays
EUR 285.6

Manual Staining System (12 Wells)

IMS001 1 ea.
EUR 246.09

Ponceau S Staining Solution, 10×

EZWB08-10x-10mL 10mL
EUR 9

Ponceau S Staining Solution, 10×

EZWB08-10x-50mL 50mL
EUR 28.8

Protein Stain-EZ J Phosphoprotein Staining Kit

BSP043 2x10minigel, 20prep
EUR 133.08

DNA Ploidy Analysis Staining Kit

K1439-1 each
EUR 705.6

DNA Ploidy Analysis Staining Kit

K1439-5 each
EUR 2402.4

Prime Juice DNA Staining Reagent

LD011-1000 1 ml
EUR 10

Novel Green DNA Staining Reagent

abx299721-100g 100 µg Ask for price

Novel Green DNA Staining Reagent

abx299721-20g 20 µg
EUR 325

Novel Green DNA Staining Reagent

abx299721-50g 50 µg Ask for price

DAPI staining kit (ready to use) 

EGY0621 10mL
EUR 85

DAPI staining kit (ready to use) 

EGY0622 50mL
EUR 185

Alcian Blue (pH 2.5) Staining Kit

AFR-1 250 ml ea.
EUR 127.28

Alcian Blue (pH 2.5) Staining Kit

AFR-2 30 ml ea.
EUR 63

Fast Coomassie Blue Protein Staining Solution

abx098912-100l 100 µl Ask for price

Fast Coomassie Blue Protein Staining Solution

abx098912-1ml 1 ml Ask for price

Fast Coomassie Blue Protein Staining Solution

abx098912-200l 200 µl Ask for price

7-AAD Viability Staining Buffer

abx090617-100tests 100 tests
EUR 260.4

Plastic Coplin Staining Jars, each

IW-2501 -
EUR 8.6

7-AAD Viability Staining Buffer

abx090617-100l 100 µl
EUR 150

7-AAD Viability Staining Buffer

abx090617-1ml 1 ml Ask for price

7-AAD Viability Staining Buffer

abx090617-200l 200 µl Ask for price

Stayrightâ„¢ Purple HRP Staining Kit

45905 5 mL
EUR 112
Description: 3,3'-Diaminobenzidine (DAB) has been applied for decades as the most commonly used IHC chromogen because it is inexpensive and sensitive for routine applications.

Stayrightâ„¢ Purple HRP Staining Kit

45905-5mL 5 mL
EUR 109
Description: 3,3'-Diaminobenzidine (DAB) has been applied for decades as the most commonly used IHC chromogen because it is inexpensive and sensitive for routine applications.

Stayrightâ„¢ Purple HRP Staining Kit

45906 50 mL
EUR 341
Description: 3,3'-Diaminobenzidine (DAB) has been applied for decades as the most commonly used IHC chromogen because it is inexpensive and sensitive for routine applications.

Stayrightâ„¢ Purple HRP Staining Kit

45906-50mL 50 mL
EUR 334
Description: 3,3'-Diaminobenzidine (DAB) has been applied for decades as the most commonly used IHC chromogen because it is inexpensive and sensitive for routine applications.

Silver protein for bodian staining 7.5-8.5% Ag

S03380 25G
EUR 634.45

Hematoxylin and Eosin Staining Kit

K1142-1000 2×500mL
EUR 62
Description: Hematoxylin and Eosin Staining,one of the most widely used staining technique in histopathology

TRAP Staining Kit with Osteoplates

KT-651 1 kit
EUR 1003

Hochst33342/PI Double Staining Kit

E37F032-100-tests 100tests
EUR 66.67
Description: Double staining kit

PAP PEN FOR IMMUNO STAINING - EACH

Z377821-1EA EACH
EUR 192.41

7-AAD Viability Staining Solution

E16FXP003 150 tests
EUR 145
Description: Available in various conjugation types.

7-AAD Viability Staining Solution

EXB0026 400 tests
EUR 44

Nalgene Box Staining 13x13x5cm - EACH

BOX1040 EACH
EUR 54

SafePinky DNA Gel Staining Solution

S1000-050 500ml
EUR 157.2

SafePinky DNA Gel Staining Solution

S1000-100 2X500ml
EUR 225.6

SafePinky DNA Gel Staining Solution

S1000-200 4X500ml
EUR 336

Disposable Slide Staining Trays - PK4

MIC5070 PK4
EUR 101.25