The molecular mechanisms of pain associated with alphaherpesvirus latency is unclear. We hypothesize that the voltage-gated sodium channels (VGSC) in dorsal root ganglion (DRG) neurons controlling the electrical impulses may have abnormal activity during infection and reactivation of latent virus. We used HSV-1 infects DRG-derived neural cell line of human HD10.6 to study the formation of viral latency, maintenance and reactivation and changes of VGSC functional expression. differentiated cells exhibited strong tetrodotoxin (TTX) sensitive sodium currents and significantly reduce the acute infection VGSC functional expression within 24 hours, and completely eliminate VGSC activity within 3 days.
A stationary state of infection mimic latency can be achieved in the presence acyclovir (ACV) for 7 days followed by 5 days of washout ACV and then the virus can remain active for three weeks. It was noted that during the formation of HSV-1 latency, loss VGSC activity caused by HSV-1 can not be blocked by the treatment of ACV. However, neurons with ACV treatment continued for 4 days showed a gradual recovery VGSC functional expression.
Furthermore, neurons VGSC latent showed higher activity compared to controls. Overall Regulation VGSC by HSV-1 during a silent infection as evidenced by an increase in the transcription and translation possibilities Nav1.7. Together these observations suggest a very complex pattern of electrophysiological changes during HSV infection DRG neurons, which may have implications for understanding the mechanisms of virus-mediated pain associated with latency and reactivation.Importance: The reactivation of the herpes virus, most often VZV and PRV, can cause nerve disorders cranial and unbearable pain. Clinical studies have also reported that HSV-1 causes occipital neuralgia and chronic postherpetic neuralgia in humans.
Work is currently closely studying the functional VGSC expression profile changes during the process of HSV-1 latency and reactivation formation using human dorsal root ganglion neurons HD 10.6 cells as an in vitro model. Our results show that the activity of VGSC eliminated after infection but continued to recover during the establishment of latency and latency neurons showed VGSC activity is even higher. This finding advances our knowledge of how the ganglion neurons generated electrical impulses as usual for normal VGSC functional expression is affected by latent viruses.
DAPI |
|||
BMD0063-10mg | Abbkine | 10 mg | EUR 119 |
Description: DAPI is a popular blue fluorescent DNA dye. |
DAPI |
|||
B1098-25 | Biovision | each | EUR 496.8 |
DAPI |
|||
B1098-5 | Biovision | each | EUR 170.4 |
DAPI |
|||
abx082063-100l | Abbexa | 100 µl | EUR 212.5 |
DAPI |
|||
abx082063-1ml | Abbexa | 1 ml | Ask for price |
DAPI |
|||
abx082063-200l | Abbexa | 200 µl | Ask for price |
DAPI |
|||
abx283157-100g | Abbexa | 100 µg | Ask for price |
DAPI |
|||
abx283157-20g | Abbexa | 20 µg | EUR 106.25 |
DAPI |
|||
abx283157-50g | Abbexa | 50 µg | EUR 237.5 |
DAPI |
|||
BMD0063-each | Abbkine | each | Ask for price |
DAPI Dilactate |
|||
17509 | AAT Bioquest | 25 mg | EUR 112 |
Description: DAPI is a fluorescent stain that binds strongly to DNA. |
DAPI Dilactate |
|||
17509-25mg | AAT Bioquest | 25 mg | EUR 109 |
Description: DAPI is a fluorescent stain that binds strongly to DNA. |
DAPI (hydrochloride) |
|||
C3362-10 | ApexBio | 10 mg | EUR 62 |
Description: A fluorescent probe, commonly used to stain DNA and chromosomes |
DAPI (hydrochloride) |
|||
C3362-25 | ApexBio | 25 mg | EUR 130 |
Description: A fluorescent probe, commonly used to stain DNA and chromosomes |
DAPI (hydrochloride) |
|||
C3362-5 | ApexBio | 5 mg | EUR 37 |
Description: A fluorescent probe, commonly used to stain DNA and chromosomes |
DAPI Dihydrochloride |
|||
561706 | MedKoo Biosciences | 5.0mg | EUR 190 |
DAPI (dihydrochloride) |
|||
HY-D0814 | MedChemExpress | 50mg | EUR 439.2 |
DAPI dihydrochloride |
|||
MB097-10MG | EWC Diagnostics | 1 unit | EUR 41.98 |
Description: DAPI dihydrochloride |
DAPI dihydrochloride |
|||
MB097-25MG | EWC Diagnostics | 1 unit | EUR 83.31 |
Description: DAPI dihydrochloride |
DAPI dihydrochloride |
|||
RM5773-25MG | EWC Diagnostics | 1 unit | EUR 119.85 |
Description: DAPI dihydrochloride |
DAPI Dihydrochloride |
|||
T19827-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: DAPI Dihydrochloride |
DAPI Dihydrochloride |
|||
T19827-1g | TargetMol Chemicals | 1g | Ask for price |
Description: DAPI Dihydrochloride |
DAPI Dihydrochloride |
|||
T19827-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: DAPI Dihydrochloride |
DAPI Dihydrochloride |
|||
T19827-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: DAPI Dihydrochloride |
DAPI Dihydrochloride |
|||
T19827-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: DAPI Dihydrochloride |
DAPI Staining Kit |
|||
abx097206-1Kit | Abbexa | 1 Kit | EUR 276 |
DAPI Staining Kit |
|||
abx097206-100l | Abbexa | 100 µl | EUR 162.5 |
DAPI Staining Kit |
|||
abx097206-1ml | Abbexa | 1 ml | Ask for price |
DAPI Staining Kit |
|||
abx097206-200l | Abbexa | 200 µl | Ask for price |
FluorLast? with DAPI |
|||
1214-20 | Biovision | each | EUR 183.6 |
DAPI Reference Standard |
|||
BLI906A-1 | Polysciences Europe GmbH | 1ml | EUR 265 |
DAPI Reference Standard |
|||
BLI906B-5 | Polysciences Europe GmbH | 5ml | EUR 522 |
DAPI Reference Standard |
|||
BLI906C-14 | Polysciences Europe GmbH | 2x7ml | EUR 1007 |
DAPI Reagent (25μg/mL) |
|||
E-CK-A163-100T | Elabscience Biotech | 100T | EUR 15 |
DAPI Reagent (25μg/mL) |
|||
E-CK-A163-200T | Elabscience Biotech | 200T | EUR 25 |
DAPI Reagent (25μg/mL) |
|||
E-CK-A163-500T | Elabscience Biotech | 500T | EUR 55 |
DAPI Reagent (25μg/mL) |
|||
E-CK-A163-50T | Elabscience Biotech | 50T | EUR 10 |
DAPI Solution(1mg/mL) |
|||
19178-91 | NACALAI TESQUE | 1ML | EUR 38.5 |
DAPI Reagent (25ug/mL) |
|||
E-CK-A163-100Tests | Elabscience Biotech | 100Tests | EUR 15 |
DAPI Reagent (25ug/mL) |
|||
E-CK-A163-200Tests | Elabscience Biotech | 200Tests | EUR 25 |
DAPI Reagent (25ug/mL) |
|||
E-CK-A163-500Tests | Elabscience Biotech | 500Tests | EUR 55 |
DAPI Reagent (25ug/mL) |
|||
E-CK-A163-50Tests | Elabscience Biotech | 50Tests | EUR 10 |
DAPI-solution(1mg/ml) |
|||
E37F17510DZ | EnoGene | 1-mL | EUR 60 |
Description: Cell-staining.-Nuclear-staining. |
Fluoroshield™ with DAPI |
|||
AR-6501-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Fluoroshield™ with DAPI |
|||
AR-6501-02 | ImmunoBioscience | 100 ml | EUR 247.1 |
Fluoroshield with DAPI & PPD |
|||
AR-6513-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Fluoroshield with DAPI & PPD |
|||
AR-6513-02 | ImmunoBioscience | 100 ml | EUR 231 |
DAPI (Molecular Biology Grade) |
|||
CE117 | GeneOn | 5 mg | EUR 72 |
DAPI (Molecular Biology Grade) |
|||
CE118 | GeneOn | 25 mg | EUR 159.6 |
DAPI (Molecular Biology Grade) |
|||
CE119 | GeneOn | 100 mg | EUR 382.8 |
Fluoroshield with DAPI & DABCO |
|||
AR-6505-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Fluoroshield with DAPI & DABCO |
|||
AR-6505-02 | ImmunoBioscience | 100 ml | EUR 247.1 |
DAPI, 10mg/mL in H2O |
|||
40043-1 | Biotium | EA | EUR 103 |
DAPI Reagent (1 ug/mL) |
|||
E-IR-R103-10mL | Elabscience Biotech | 10mL | EUR 35 |
DAPI Reagent (1 ug/mL) |
|||
E-IR-R103-50mL | Elabscience Biotech | 50mL | EUR 105 |
DAPI Reagent (1 ug/mL) |
|||
E-IR-R103-5mL | Elabscience Biotech | 5mL | EUR 20 |
DAPI Reagent (1 ug/mL) |
|||
E-IR-R103-each | Elabscience Biotech | each | Ask for price |
Fluoroshield with DAPI & Propylgallate |
|||
AR-6506-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Fluoroshield with DAPI & Propylgallate |
|||
AR-6506-02 | ImmunoBioscience | 100 ml | EUR 247.1 |
FluorLast? with DAPI and DABCO |
|||
1218-20 | Biovision | each | EUR 183.6 |
Fluoromount Mounting Medium with DAPI |
|||
42734051-1 | Glycomatrix | 20 mL | EUR 76.14 |
FluoroQuestâ„¢ Mounting Medium with DAPI |
|||
20004 | AAT Bioquest | 50 mL | EUR 112 |
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. |
FluoroQuestâ„¢ Mounting Medium with DAPI |
|||
20004-50mL | AAT Bioquest | 50 mL | EUR 109 |
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. |
OOSB00007-20ML - Dapi-Fluoromount-G |
|||
OOSB00007-20ML | Aviva Systems Biology | 20mL | EUR 79 |
DAPI staining kit (ready to use) |
|||
EGY0621 | EnoGene | 10mL | EUR 85 |
DAPI staining kit (ready to use) |
|||
EGY0622 | EnoGene | 50mL | EUR 185 |
Annexin V-PE/DAPI Apoptosis Kit |
|||
E-CK-A256-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-PE/DAPI Apoptosis Kit |
|||
E-CK-A256-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-PE/DAPI Apoptosis Kit |
|||
E-CK-A256-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-PE/DAPI Apoptosis Kit |
|||
E-CK-A256-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-APC/DAPI Apoptosis Kit |
|||
E-CK-A258-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-APC/DAPI Apoptosis Kit |
|||
E-CK-A258-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-APC/DAPI Apoptosis Kit |
|||
E-CK-A258-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-APC/DAPI Apoptosis Kit |
|||
E-CK-A258-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-FITC/DAPI Apoptosis Kit |
|||
E-CK-A252-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-FITC/DAPI Apoptosis Kit |
|||
E-CK-A252-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-FITC/DAPI Apoptosis Kit |
|||
E-CK-A252-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-FITC/DAPI Apoptosis Kit |
|||
E-CK-A252-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-EGFP/DAPI Apoptosis Kit |
|||
E-CK-A260-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-EGFP/DAPI Apoptosis Kit |
|||
E-CK-A260-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-EGFP/DAPI Apoptosis Kit |
|||
E-CK-A260-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-EGFP/DAPI Apoptosis Kit |
|||
E-CK-A260-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-AF647/DAPI Apoptosis Kit |
|||
E-CK-A254-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-AF647/DAPI Apoptosis Kit |
|||
E-CK-A254-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-AF647/DAPI Apoptosis Kit |
|||
E-CK-A254-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-AF647/DAPI Apoptosis Kit |
|||
E-CK-A254-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-AF488/DAPI Apoptosis Kit |
|||
E-CK-A278-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-AF488/DAPI Apoptosis Kit |
|||
E-CK-A278-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-AF488/DAPI Apoptosis Kit |
|||
E-CK-A278-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-AF488/DAPI Apoptosis Kit |
|||
E-CK-A278-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-ER780/DAPI Apoptosis Kit |
|||
E-CK-A280-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-ER780/DAPI Apoptosis Kit |
|||
E-CK-A280-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-ER780/DAPI Apoptosis Kit |
|||
E-CK-A280-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-ER780/DAPI Apoptosis Kit |
|||
E-CK-A280-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Anti-Fade Mounting Medium (With DAPI) |
|||
abx090690-10ml | Abbexa | 10 ml | EUR 243.6 |
Anti-Fade Mounting Medium (With DAPI) |
|||
abx090690-100l | Abbexa | 100 µl | EUR 137.5 |
Anti-Fade Mounting Medium (With DAPI) |
|||
abx090690-1ml | Abbexa | 1 ml | Ask for price |
Anti-Fade Mounting Medium (With DAPI) |
|||
abx090690-200l | Abbexa | 200 µl | Ask for price |
DAPI in Fluorguard™ (0.3 µg/ml) |
|||
F201 | Insitus Biotechnologies | 1 ml | Ask for price |
DAPI in Fluorguard™ (0.5 µg/ml) |
|||
F203 | Insitus Biotechnologies | 1 ml | Ask for price |
DAPI in Fluorguard™ (1 µg/ml) |
|||
F204 | Insitus Biotechnologies | 1 ml | Ask for price |
EverBrite™ Mounting Medium with DAPI |
|||
23002-1 | Biotium | EA | EUR 172 |
Annexin V-Cyanine5/DAPI Apoptosis Kit |
|||
E-CK-A262-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-Cyanine5/DAPI Apoptosis Kit |
|||
E-CK-A262-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-Cyanine5/DAPI Apoptosis Kit |
|||
E-CK-A262-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-Cyanine5/DAPI Apoptosis Kit |
|||
E-CK-A262-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-PE/TR/DAPI Apoptosis Kit |
|||
E-CK-A272-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-PE/TR/DAPI Apoptosis Kit |
|||
E-CK-A272-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-PE/TR/DAPI Apoptosis Kit |
|||
E-CK-A272-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-PE/TR/DAPI Apoptosis Kit |
|||
E-CK-A272-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Immuno Fluoro Mount with DABCO and DAPI |
|||
AR-6519-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Immuno Fluoro Mount with DABCO and DAPI |
|||
AR-6519-02 | ImmunoBioscience | 100 ml | EUR 207.2 |
Annexin V-PE/Cyanine5/DAPI Apoptosis Kit |
|||
E-CK-A264-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-PE/Cyanine5/DAPI Apoptosis Kit |
|||
E-CK-A264-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-PE/Cyanine5/DAPI Apoptosis Kit |
|||
E-CK-A264-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-PE/Cyanine5/DAPI Apoptosis Kit |
|||
E-CK-A264-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit |
|||
E-CK-A266-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit |
|||
E-CK-A266-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit |
|||
E-CK-A266-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit |
|||
E-CK-A266-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-PE/Cyanine7/DAPI Apoptosis Kit |
|||
E-CK-A268-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-PE/Cyanine7/DAPI Apoptosis Kit |
|||
E-CK-A268-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-PE/Cyanine7/DAPI Apoptosis Kit |
|||
E-CK-A268-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-PE/Cyanine7/DAPI Apoptosis Kit |
|||
E-CK-A268-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-APC/Cyanine7/DAPI Apoptosis Kit |
|||
E-CK-A270-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-APC/Cyanine7/DAPI Apoptosis Kit |
|||
E-CK-A270-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-APC/Cyanine7/DAPI Apoptosis Kit |
|||
E-CK-A270-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-APC/Cyanine7/DAPI Apoptosis Kit |
|||
E-CK-A270-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Fluorescent Mounting Medium with DAPI, 18 ml |
|||
E19-18 | IHC World | - | EUR 125 |
Glycerol mounting medium with DAPI and DABCO |
|||
AR-6510-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Glycerol mounting medium with DAPI and DABCO |
|||
AR-6510-02 | ImmunoBioscience | 100 ml | EUR 207.2 |
DAPI (4',6-Diamidino-2-phenylindole dihy |
|||
PCT1539-25MG | EWC Diagnostics | 1 unit | EUR 77.94 |
Description: DAPI (4',6-Diamidino-2-phenylindole dihy |
DAPI (4',6-Diamidino-2-phenylindole dihy |
|||
PCT1539-5MG | EWC Diagnostics | 1 unit | EUR 18.69 |
Description: DAPI (4',6-Diamidino-2-phenylindole dihy |
EverBrite™ Hardset Mounting Medium with DAPI |
|||
23004-1 | Biotium | EA | EUR 194 |
FluoroQuestâ„¢ Anti-fading Mounting Medium with DAPI |
|||
20005 | AAT Bioquest | 20 mL | EUR 216 |
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. |
FluoroQuestâ„¢ Anti-fading Mounting Medium with DAPI |
|||
20005-20mL | AAT Bioquest | 20 mL | EUR 211 |
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. |
Anti-fluorescence quenching sealing Kit (including DAPI) |
|||
EGY073 | EnoGene | 100T | EUR 60 |
DAPI-[4',6-Diamidino-2-phenylindole,-dihydrochloride] |
|||
E37F17510 | EnoGene | 10-mg | EUR 260 |
Description: Cell-staining.-Nuclear-staining. |
DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) |
|||
B551 | ABM | 0.2 ml | EUR 85 |
Dye 937 |
|||
HY-15422 | MedChemExpress | 5mg | EUR 514.8 |
Dye 993 |
|||
HY-15423 | MedChemExpress | 5mg | EUR 514.8 |
Dye 937 |
|||
T18985-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Dye 937 |
Dye 937 |
|||
T18985-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Dye 937 |
Dye 937 |
|||
T18985-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Dye 937 |
Dye 937 |
|||
T18985-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Dye 937 |
Dye 937 |
|||
T18985-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Dye 937 |
Dye 993 |
|||
T18986-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Dye 993 |
Dye 993 |
|||
T18986-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Dye 993 |
Dye 993 |
|||
T18986-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Dye 993 |
Dye 993 |
|||
T18986-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Dye 993 |