KLHL1 Controls CaV3.2 Expression in DRG Neurons and Mechanical Sensitivity to Pain.

Dorsal root ganglion (DRG) neurons course of ache signaling by specialised nociceptors situated in their peripheral endings. It has lengthy been established low voltage-activated (LVA) CaV3.2 calcium channels management neuronal excitability throughout sensory notion in these neurons. Silencing CaV3.2 exercise with antisense RNA or genetic ablation outcomes in anti-nociceptive, anti-hyperalgesic and anti-allodynic results. CaV3.2 channels are regulated by many proteins (Weiss and Zamponi, 2017), together with KLHL1, a neuronal actin-binding protein that stabilizes channel exercise by recycling it again to the plasma membrane by the recycling endosome.

We explored whether or not manipulation of KLHL1 ranges and thereby operate as a CaV3.2 modifier can modulate DRG excitability and mechanical ache transmission or sensitivity to ache. We first assessed the mechanical sensitivity threshold and DRG properties in the KLHL1 KO mouse mannequin. KO DRG neurons exhibited smaller T-type present density in contrast to WT with out important modifications in voltage dependence, as anticipated in the absence of its modulator.

Western blot evaluation confirmed CaV3.2 however not CaV3.1, CaV3.3, CaV2.1, or CaV2.2 protein ranges have been considerably decreased; and lowered neuron excitability and decreased ache sensitivity have been additionally discovered in the KLHL1 KO mannequin. Analogously, transient down-regulation of KLHL1 ranges in WT mice with viral supply of anti-KLHL1 shRNA additionally resulted in decreased ache sensitivity. These two experimental approaches affirm KLHL1 as a physiological modulator of excitability and ache sensitivity, offering a novel goal to management peripheral ache.

Electroacupuncture (EA) has efficient analgesic results. Our earlier research demonstrated that the upregulation of P2X3 receptors in the dorsal root ganglia (DRG) may take part in heroin withdrawal-induced hyperalgesia. The goal of this research is to additional discover whether or not 2 Hz EA reduces heroin relapse related to its analgesic impact and whether or not P2X3 receptors in the DRG are concerned in this course of. 2 Hz EA was adopted to deal with the heroin SA rats in the current research. Heroin-seeking and ache sensitivity have been evaluated.

The expression of P2X3 receptors in the DRG was detected. Our outcomes confirmed that in contrast with the management group, the reinstatement, thermal hyperalgesia, and mechanical allodynia of the heroin-addicted group have been elevated considerably. The expression of P2X3 receptors in the DRG was elevated markedly. After being handled utilizing 2 Hz EA, reinstatement was lowered, hyperalgesia was decreased, and the upregulated expression of P2X3 receptors in the DRG had decreased considerably in contrast to that in the heroin-addicted group.

KLHL1 Controls CaV3.2 Expression in DRG Neurons and Mechanical Sensitivity to Pain.
KLHL1 Controls CaV3.2 Expression in DRG Neurons and Mechanical Sensitivity to Pain.

Consequently, our outcomes indicated that 2 Hz EA was an efficient technique for treating heroin-induced hyperalgesia and serving to stop relapse, and the potential mechanism may be associated to the downregulation of P2X3 receptor expression in the DRG.

Tide Fluorâ„¢ 8WS alkyne [TF8WS alkyne] *Near Infrared Emission*

2307-1mg 1 mg
EUR 222
Description: Tide Fluor™ 8WS (TF8WS) family has the spectral properties similar to those of IRDye 800.

Tide Fluor™ 8WS azide [TF8WS azide] *Near Infrared Emission*

2306 1 mg
EUR 222

Tide Fluor™ 8WS amine [TF8WS amine] *Near Infrared Emission*

2336 1 mg
EUR 222

Tide Fluor™ 8WS alkyne [TF8WS alkyne] *Near Infrared Emission*

2307 1 mg
EUR 222

Tide Fluorâ„¢ 8WS maleimide [TF8WS maleimide] *Near Infrared Emission*

2337-1mg 1 mg
EUR 222
Description: Tide Fluor™ 8WS (TF8WS) family has the spectral properties similar to those of IRDye 800.

Tide Fluor™ 8WS maleimide [TF8WS maleimide] *Near Infrared Emission*

2337 1 mg
EUR 222

Tide Fluorâ„¢ 8WS, succinimidyl ester [TF8WS SE]*Near Infrared Emission*

2338-1mg 1 mg
EUR 109
Description: Tide Fluor™ 8WS (TF8WS) family has the spectral properties similar to those of IRDye 800.

Tide Fluor™ 8WS, succinimidyl ester [TF8WS SE]*Near Infrared Emission*

2338 1 mg
EUR 109

DAPI

B1098-25 each
EUR 496.8

DAPI

B1098-5 each
EUR 170.4

DAPI

abx082063-10mg 10 mg
EUR 276

DAPI Dilactate

17509 25 mg
EUR 109

DAPI Dilactate

17509-25mg 25 mg
EUR 109
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI (hydrochloride)

C3362-10 10 mg
EUR 146.4

DAPI (hydrochloride)

C3362-25 25 mg
EUR 240

DAPI (hydrochloride)

C3362-5 5 mg
EUR 111.6

DAPI (dihydrochloride)

HY-D0814 50mg
EUR 439.2

DAPI Staining Kit

abx097206-1Kit 1 Kit
EUR 276

FluorLast? with DAPI

1214-20 each
EUR 183.6

DAPI (Molecular Biology Grade)

CE117 5 mg
EUR 72

DAPI (Molecular Biology Grade)

CE118 25 mg
EUR 159.6

DAPI (Molecular Biology Grade)

CE119 100 mg
EUR 382.8

FluorLast? with DAPI and DABCO

1218-20 each
EUR 183.6

FluoroQuestâ„¢ Mounting Medium with DAPI

20004-50mL 50 mL
EUR 109
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears.

Anti-Fade Mounting Medium (With DAPI)

abx090690-10ml 10 ml
EUR 243.6

FluoroQuest™ Mounting Medium with DAPI

20004 50 mL
EUR 109

EverBrite Hardset Mounting Medium with DAPI

23004 10mL
EUR 255.6
Description: Minimum order quantity: 1 unit of 10mL

FluoroQuestâ„¢ Anti-fading Mounting Medium with DAPI

20005-20mL 20 mL
EUR 211
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears.

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride)

B551 0.2 ml
EUR 129.6

FluoroQuest™ Anti-fading Mounting Medium with DAPI

20005 20 mL
EUR 211

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17510 10 mg
EUR 86

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17511 100 mg
EUR 222

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17513 25 mg
EUR 109

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17510-10mg 10 mg
EUR 86
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17511-100mg 100 mg
EUR 222
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*

17513-25mg 25 mg
EUR 109
Description: DAPI is a fluorescent stain that binds strongly to DNA.

Human 4’,6-Diamidino-2-phenylindole dihydrochloride(DAPI)ELISA kit

QY-E05538 96T
EUR 433.2

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *10 mM solution in water*

17507 2 mL
EUR 86

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *10 mM solution in water*

17507-2mL 2 mL
EUR 86
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining

AR1176 10mL(100 assys)
EUR 78

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining

AR1177 50mL(500 assys)
EUR 121.2

Dapivirine

HY-14266 5mg
EUR 183.6

Dapivirine (TMC120)

A8554-25 25 mg
EUR 517.2
Description: Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor with a favorable safety profile following vaginal application.

Dapivirine (TMC120)

A8554-5 5 mg
EUR 201.6
Description: Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor with a favorable safety profile following vaginal application.

Dapivirine (TMC120)

A8554-5.1 10 mM (in 1mL DMSO)
EUR 212.4
Description: Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor with a favorable safety profile following vaginal application.

Dapiprazole (hydrochloride)

HY-A0142A 25mg
EUR 241.2

Anti-CD40LG (Dapirolizumab pegol)-MC-MMAF ADC

ADC-W-2446 1mg Ask for price
Description: This ADC product is comprised of an anti-CD40LG Fab' fragment conjugated via a MC linker to MMAF

Anti-CD40LG (Dapirolizumab pegol)-SMCC-DM1 ADC

ADC-W-2444 1mg Ask for price
Description: This ADC product is comprised of an anti-CD40LG Fab' fragment conjugated via a SMCC linker to DM1

Anti-CD40LG (Dapirolizumab pegol)-SPDB-DM4 ADC

ADC-W-2445 1mg Ask for price
Description: This ADC product is comprised of an anti-CD40LG Fab' fragment conjugated via a SPDB linker to DM4

Anti-CD40LG (Dapirolizumab pegol)-MC-Vc-PAB-MMAE ADC

ADC-W-2447 1mg Ask for price
Description: This ADC product is comprised of an anti-CD40LG Fab' fragment conjugated via a MC-Vc linker to MMAE

Anti-CD40LG (Dapirolizumab pegol)-MC-Vc-PAB-SN38 ADC

ADC-W-2448 1mg Ask for price
Description: This ADC product is comprised of an anti-CD40LG Fab' fragment conjugated via a MC-Vc-PAB linker to SN38

Borneol 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside

TBW01077 10mg Ask for price

(-)-Syringaresnol-4-O-?-D-apiofuranosyl-(1?2)-?-D-glucopyranoside

N2462-10 10 mg
EUR 686.4
Description: Extracted from Syringa oblata;Store the product in sealed, cool and dry condition

Anti-CD40LG (Dapirolizumab pegol)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC

ADC-W-2449 1mg Ask for price
Description: This ADC product is comprised of an anti-CD40LG Fab' fragment conjugated via a MC-Vc-PAB-DMEA-(PEG2) linker to duocarmycin SA

EMI1(EMI1/1176) Antibody

BNC941176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF594 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC941176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF594 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC801176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF680 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC801176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF680 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC811176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF680R conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC811176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF680R conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC701176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF770 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC701176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF770 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC881176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF488A conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC881176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF488A conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC051176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF405M conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC051176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF405M conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC041176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF405S conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC041176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF405S conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC401176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF640R conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC401176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF640R conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNCB1176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), Biotin conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNCB1176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), Biotin conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNCAP1176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNCAP1176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNCA1176-250 250uL
EUR 459.6
Description: Primary antibody against EMI1(EMI1/1176), APC conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNCR1176-250 250uL
EUR 459.6
Description: Primary antibody against EMI1(EMI1/1176), RPE conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNCP1176-250 250uL
EUR 459.6
Description: Primary antibody against EMI1(EMI1/1176), PerCP conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNUM1176-50 50uL
EUR 474
Description: Primary antibody against EMI1(EMI1/1176), 1mg/mL

EMI1(EMI1/1176) Antibody

BNCH1176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNCH1176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNUB1176-100 100uL
EUR 250.8
Description: Primary antibody against EMI1(EMI1/1176), Concentration: 0.2mg/mL

EMI1(EMI1/1176) Antibody

BNUB1176-500 500uL
EUR 549.6
Description: Primary antibody against EMI1(EMI1/1176), Concentration: 0.2mg/mL

EMI1(EMI1/1176) Antibody

BNC611176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF660R conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC611176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF660R conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC551176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF555 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC551176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF555 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC431176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF543 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC431176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF543 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC681176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF568 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC681176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF568 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC471176-100 100uL
EUR 238.8
Description: Primary antibody against EMI1(EMI1/1176), CF647 conjugate, Concentration: 0.1mg/mL

EMI1(EMI1/1176) Antibody

BNC471176-500 500uL
EUR 652.8
Description: Primary antibody against EMI1(EMI1/1176), CF647 conjugate, Concentration: 0.1mg/mL

Monoclonal EMI1 (Early Mitotic Inhibitor-1) Antibody, Clone: EMI1/1176

AMM00743G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human EMI1 (Early Mitotic Inhibitor-1). The antibodies are raised in Mouse and are from clone EMI1/1176. This antibody is applicable in WB, IHC and IF, FC

Monoclonal EMI1 (Early Mitotic Inhibitor-1) Antibody - With BSA and Azide, Clone: EMI1/1176

AMM00744G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human EMI1 (Early Mitotic Inhibitor-1) - With BSA and Azide. The antibodies are raised in Mouse and are from clone EMI1/1176. This antibody is applicable in WB, IHC and IF, FC

Monoclonal EMI1 (Early Mitotic Inhibitor-1) Antibody - Without BSA and Azide, Clone: EMI1/1176

AMM00745G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human EMI1 (Early Mitotic Inhibitor-1) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone EMI1/1176. This antibody is applicable in WB, IHC and IF, FC

Anti-EMI1 Antibody Clone EMI1/1176, Unconjugated-100ug

26271-MSM1-P1 100ug
EUR 513.6

EMI2 Peptide

45-533P 0.1 mg
EUR 405.6
Description: FBXO43 / EMI2 Peptide

Emi1 Antibody

49892-100ul 100ul
EUR 399.6

Emi1 Antibody

49892-50ul 50ul
EUR 286.8

DAP13 (DAP13) Antibody

abx232237-100ug 100 ug
EUR 577.2

Emi1 Conjugated Antibody

C49892 100ul
EUR 476.4

EMILIN-3 (EMILIN3) Antibody

abx027524-400ul 400 ul
EUR 627.6

EMILIN-3 (EMILIN3) Antibody

abx027524-80l 80 µl
EUR 343.2

Human EMILIN- 2, EMILIN2 ELISA KIT

ELI-48120h 96 Tests
EUR 988.8

Mouse EMILIN- 2, Emilin2 ELISA KIT

ELI-26594m 96 Tests
EUR 1038

Mouse EMILIN- 3, Emilin3 ELISA KIT

ELI-27666m 96 Tests
EUR 1038

Human EMILIN- 3, EMILIN3 ELISA KIT

ELI-32236h 96 Tests
EUR 988.8

Human EMILIN-1(EMILIN1) ELISA kit

CSB-EL007639HU-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human EMILIN-1 (EMILIN1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human EMILIN-1(EMILIN1) ELISA kit

1-CSB-EL007639HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human EMILIN-1(EMILIN1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human EMILIN1/ EMILIN-1 ELISA Kit

E0784Hu 1 Kit
EUR 685.2

DAP5 (DAP5) Antibody

abx232239-100ug 100 ug
EUR 577.2

Emilin2 ELISA Kit| Mouse EMILIN-2 ELISA Kit

EF014768 96 Tests
EUR 826.8

Early Mitotic Inhibitor 2 (EMI2) Antibody

abx432213-200ul 200 ul
EUR 460.8

DAP13 antibody

22408-100ul 100ul
EUR 468

DAP12 antibody

20R-1820 100 ug
EUR 807.6
Description: Rabbit polyclonal DAP12 antibody

DAP10 Antibody

abx430406-200ul 200 ul
EUR 460.8

DAP12 Antibody

5570R-100 each
EUR 424.8

DAP12 Antibody

5570R-30T each
EUR 175.2

DAP12 antibody

70R-12373 100 ug
EUR 552
Description: Rabbit polyclonal DAP12 antibody

DAP12 Antibody

49944-100ul 100ul
EUR 399.6

DAP12 Antibody

49944-50ul 50ul
EUR 286.8

DAP13 ELISA KIT|Human

EF009004 96 Tests
EUR 826.8

EMI1 Antibody (Early Mitotic Inhibitor-1)

V7090-100UG 100 ug
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V7090-20UG 20 ug
EUR 153.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V7090IHC-7ML 7 ml
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V7090SAF-100UG 100 ug
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527-100UG 100 ug
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527-20UG 20 ug
EUR 153.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527IHC-7ML 7 ml
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527SAF-100UG 100 ug
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

anti- DAP13 antibody

FNab02237 100µg
EUR 606.3
Description: Antibody raised against DAP13

Recombinant Pichia pastoris EMI5 Protein (aa 1-190)

VAng-Cr6595-inquire inquire Ask for price
Description: Pichia pastoris (strain GS115 / ATCC 20864) Succinate dehydrogenase assembly factor 2, mitochondrial (EMI5), partial, recombinant protein.

DAP12 Blocking Peptide

5570RBP-50 each
EUR 183.6

DAP12 Blocking Peptide

33R-11048 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DAP12 antibody, catalog no. 70R-12373

D-AP5

20-abx076757
  • EUR 878.40
  • EUR 376.80
  • 25 mg
  • 5 mg

D-AP5.Na

20-abx076780
  • EUR 910.80
  • EUR 410.40
  • 25 mg
  • 5 mg

D-AP4

B6201-10 10 mg
EUR 517.2

D-AP4

B6201-50 50 mg
EUR 1987.2

D-AP5

B6205-10 10 mg
EUR 195.6

D-AP5

B6205-100 100 mg
EUR 961.2

D-AP5

B6205-5 5 mg
EUR 134.4

D-AP5

B6205-50 50 mg
EUR 661.2

D-AP7

B6212-10 10 mg
EUR 388.8

D-AP7

B6212-50 50 mg
EUR 1444.8

D-AP5

HY-100714A 5mg
EUR 170.4

Polyclonal EMI2 / FBXO43 Antibody (N-Terminus)

APR02212G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EMI2 / FBXO43 (N-Terminus). This antibody is tested and proven to work in the following applications:

Mouse EMI domain- containing protein 1, Emid1 ELISA KIT

ELI-48119m 96 Tests
EUR 1038

Human EMI domain- containing protein 1, EMID1 ELISA KIT

ELI-31622h 96 Tests
EUR 988.8

DAP10 Signaling Fragment

5-01031 4 x 1mg Ask for price

EMI Domain-Containing Protein 2 (EMID2) Antibody

20-abx215146
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

EMI Domain-Containing Protein 1 (EMID1) Antibody

abx027432-400ul 400 ul
EUR 627.6

EMI Domain-Containing Protein 1 (EMID1) Antibody

abx027432-80l 80 µl
EUR 343.2

EMI Domain-Containing Protein 2 (EMID2) Antibody

abx029671-400ul 400 ul
EUR 627.6

EMI Domain-Containing Protein 2 (EMID2) Antibody

abx029671-80l 80 µl
EUR 343.2

Polyclonal DAP12 Antibody

APR15685G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human DAP12 . This antibody is tested and proven to work in the following applications:

Polyclonal DAP12 Antibody

APR15686G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DAP12 . This antibody is tested and proven to work in the following applications:

DAP12 Conjugated Antibody

C49944 100ul
EUR 476.4

DAP3 siRNA

20-abx913558
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

DAP3 siRNA

20-abx913559
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

DAP3 Peptide

45-046P 0.1 mg
EUR 405.6
Description: (CT) DAP3 Peptide

DAP3 Rabbit pAb

A3342-100ul 100 ul
EUR 369.6

DAP3 Rabbit pAb

A3342-200ul 200 ul
EUR 550.8

DAP3 Rabbit pAb

A3342-20ul 20 ul Ask for price

DAP3 Rabbit pAb

A3342-50ul 50 ul Ask for price

DAP3 Rabbit pAb

A2714-100ul 100 ul
EUR 369.6

DAP3 Rabbit pAb

A2714-200ul 200 ul
EUR 550.8

DAP3 Rabbit pAb

A2714-20ul 20 ul Ask for price

DAP3 Rabbit pAb

A2714-50ul 50 ul
EUR 267.6

DAP3 Rabbit pAb

A7003-100ul 100 ul
EUR 369.6

DAP3 Rabbit pAb

A7003-200ul 200 ul
EUR 550.8

DAP3 Rabbit pAb

A7003-20ul 20 ul
EUR 219.6

DAP3 Rabbit pAb

A7003-50ul 50 ul
EUR 267.6

Rat DAP6 ELISA Kit

ERD0144 96Tests
EUR 625.2

Dap/ Rat Dap ELISA Kit

ELI-31052r 96 Tests
EUR 1063.2

DAP5 antibody

22896-100ul 100ul
EUR 468

DAP3 Antibody

31066-100ul 100ul
EUR 302.4

DAP3 Antibody

31066-50ul 50ul
EUR 224.4

DAP3 antibody

70R-10345 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal DAP3 antibody

DAP1 antibody

70R-11726 100 ug
EUR 536.4
Description: Rabbit polyclonal DAP1 antibody

DAP5 antibody

70R-12601 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal DAP5 antibody

DAP1 antibody

70R-15457 100 ug
EUR 392.4
Description: Rabbit polyclonal DAP1 antibody

DAP3 antibody

70R-16736 50 ul
EUR 522
Description: Rabbit polyclonal DAP3 antibody

DAP1 Antibody

3261-100 each
EUR 430.8

DAP3 Antibody

1-CSB-PA006497ESR2HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against DAP3. Recognizes DAP3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

DAP3 Antibody

1-CSB-PA006497GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against DAP3. Recognizes DAP3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB

DAP3 Antibody

DF13390 100ul
EUR 420

DAP3 Antibody

1-CSB-PA922061
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against DAP3. Recognizes DAP3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:10-1:50

DAP-3 Antibody

20-abx141935
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

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